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Grant number: 12/14614-8
Support Opportunities:Regular Research Grants
Duration: October 01, 2012 - September 30, 2014
Field of knowledge:Biological Sciences - Pharmacology - Ethnopharmacology
Principal Investigator:José Maurício Sforcin
Grantee:José Maurício Sforcin
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Propolis is a resinous product, made by bees from several parts of plants, showing biological and pharmacological properties, and a potential to pharmaceutical and food industry. Caries and periodontal diseases are infectious diseases with failure to balance the oral microbiota, whose agents may be transmitted. Chlorexidine has been used as an anticarie agent, but its use is controversial due to side effects. Thus, there is a search for new products with antimicrobial action and fewer side effects. Herein, we aim to investigate not only propolis but also an antimicrobial agent (chlorexidine), as well as the association propolis/chlorexidine directly on S. mutans or the action on monocytes against this bacteria. We will determine the effect of these variables on S. mutans, determining the minimal inhibitory concentration, as well as on monocytes, evaluating the production of pro- and anti-inflammatory cytokines and the bactericidal activity of these cells. The quality of propolis or propolis/chlorexidine will be assessed regarding its stability or contamination according to the shelf time, in order to develop a pharmaceutical product, demonstrating the importance of this research project. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTIAGO, KARINA BASSO; CONTI, BRUNO JOSE; CARDOSO, ELIZA DE OLIVEIRA; GOLIM, MARJORIE DE ASSIS; SFORCIN, JOSE MAURICIO. Immunomodulatory/anti-inflammatory effects of a propolis-containing mouthwash on human monocytes. PATHOGENS AND DISEASE, v. 74, n. 8, . (12/14614-8, 11/22112-0)
CONTI, BRUNO J.; SANTIAGO, KARINA B.; BUFALO, MICHELLE C.; HERRERA, YAHIMA F.; ALDAY, EFRAIN; VELAZQUEZ, CARLOS; HERNANDEZ, JAVIER; SFORCIN, JOSE M.. Modulatory effects of propolis samples from Latin America (Brazil, Cuba and Mexico) on cytokine production by human monocytes. Journal of Pharmacy and Pharmacology, v. 67, n. 10, p. 1431-1438, . (12/14614-8)

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