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Periodontal disease in adults with isolated growth hormone deficiency: clinical, microbiological and immunological aspects.

Grant number: 11/24005-6
Support Opportunities:Regular Research Grants
Duration: September 01, 2012 - August 31, 2014
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Francisco Emílio Pustiglioni
Grantee:Francisco Emílio Pustiglioni
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


There is no information in the literature regarding the influence of Growth Hormone Deficiency in the immuno-inflammatory mechanisms involved in periodontal tissues destruction. The aim of this study is to test the hypothesis that the isolated growth hormone deficiency (IGHD) leads to an inflammatory response and bone homeostasis change, increasing the inflammatory process, regardless a change in the microbiota. The sample will comprise 32 IGHD individuals and 32 controls, matched for age, gender, socio-economic condition, smoking status and diabetes. A follow-up periodontal clinical examination (3 years) will be performed in order to assess periodontal disease severity and progression in groups, as well as subgingival biofilm to check periodontal pathogens levels and proportions, i.e. A actinomycetemcomitans, P. gingivalis, T. forsythia and T. denticola. Also, gingival crevicular fluid will be collected to analyze gingival crevicular fluid inflammatory cytokines and osteoclastogenesis mediators. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARAUJO, I. M. P.; ALBUQUERQUE-SOUZA, E.; AGUIAR-OLIVEIRA, M. H.; HOLZHAUSEN, M.; OLIVEIRA-NETO, L. A.; SALVATORI, R.; SARAIVA, L.; MAYER, M. P. A.; PANNUTI, C. M.; RIBEIRO, A. O.; et al. Immunological and microbiological periodontal profiles in isolated growth hormone deficiency. Journal of Periodontology, v. 89, n. 11, p. 1351-1361, . (11/24005-6, 15/07396-2)

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