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Bioactive composites: effect of different calcium phosphate compounds and organic matrix composition on the remineralizing potential and physicochemical properties of experimental materials

Grant number: 12/04532-4
Support Opportunities:Regular Research Grants
Duration: September 01, 2012 - August 31, 2014
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Roberto Ruggiero Braga
Grantee:Roberto Ruggiero Braga
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The development of bioactive composites is a challenge for researchers searching for formulations with remineralizing action without compromising the physical and chemical properties of the restorative material. Objectives: the aim of this study is to evaluate the bioactivity potential, degree of conversion, volumetric shrinkage and mechanical properties of experimental composites containing calcium phosphate compounds. The experiment will test composites presenting different amounts of inorganic filler and the effect of the addition of HEMA to the organic matrix. Materials and methods: in the first part of the project, amorphous calcium phosphate (ACP), dicalcium phosphate anhydrous (DCPA) or tricalcium phosphate (TCP) particles will be incorporated in an organic matrix containing BisGMA and TEGDMA to evaluate the buffering capacity and release of calcium and phosphate ions by inductively coupled plasma-optical emission spectroscopy (ICP-OES). The second stage will determine the effects of adding 40% (by weight) of calcium phosphate in composites containing different amounts of barium glass on the degree of conversion (FTIR spectroscopy), volumetric shrinkage (Helium pycnometer), fracture toughness (method "single-edge notched beam"), biaxial flexure strength and elastic modulus. The bioactivity of these materials will also be evaluated. Effects of HEMA addition to the organic matrix will be evaluated according to the same variables. Data will be submitted to analysis of variance (ANOVA) and a Tukey's post-hoc test (p<0.05%). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, MARCELA CHARANTOLA; REIS HEWER, THIAGO LEWIS; DE SOUZA BRITO, GIANCARLO ESPOSITO; ARANA-CHAVEZ, VICTOR ELIAS; BRAGA, ROBERTO RUGGIERO. Calcium phosphate nanoparticles functionalized with a dimethacrylate monomer. Materials Science & Engineering C-Materials for Biological Applications, v. 45, p. 122-126, . (12/04532-4)
CHIARI, MARINA D. S.; RODRIGUES, MARCELA C.; XAVIER, TATHY A.; DE SOUZA, EUGEN M. N.; ARANA-CHAVEZ, VICTOR E.; BRAGA, ROBERTO R.. Mechanical properties and ion release from bioactive restorative composites containing glass fillers and calcium phosphate nano-structured particles. Dental Materials, v. 31, n. 6, p. 726-733, . (12/25253-6, 12/04532-4)
RODRIGUES, MARCELA C.; NATALE, LIVIA C.; ARANA-CHAVES, VICTOR E.; BRAGA, ROBERTO R.. Calcium and phosphate release from resin-based materials containing different calcium orthophosphate nanoparticles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 103, n. 8, p. 1670-1678, . (12/04532-4)

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Filed patent(s) as a result of this research project

PROCESSO DE PRODUÇÃO DE NANOPARTÍCULAS DE FOSFATO DE CÁLCIO FUNCIONALIZADAS COM MONÔMEROS ORGÂNICOS E SEU USO BR1020130231134 - Universidade de São Paulo (USP) . Roberto Ruggiero Braga ; Giancarlo Espósito De Souza Brito ; Thiago Lewis Reis Hewer ; Marcela Charantola Rodrigues - September 2013, 10