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Consequences of sleep restriction during pregnancy on the development of sensory-motor and sexual behavior in the offspring

Abstract

The curtailment in sleep time, which is inherent to a modern lifestyle, may lead to clear repercussions upon one's health and wellbeing. These impairments significantly impact the endocrine system, and changes in sexual behavior can affect reproductive function. In fact, the outcomes of sleep restriction (SR) can be extended to pregnancy. The aim of this study is to evaluate the effects of SR during pregnancy on offspring development. Hannover-Wistar female rats will be subjected to SR throughout the pregnant period (21 days). In this protocol, the females will have the opportunity to sleep 6 hours a day and will be deprived of paradoxical sleep for 18 hours. After birth, the offspring will be analyzed for physical and reflexology since the first day of postnatal life until adulthood. At 3 months old, sexual behavior will be examined in both males and females. At the end of the experiments, blood will be collected for later hormonal assays. We expecte to provide evidence of the overall consequences of SR during pregnancy on the development of sensory-motor and sexual behavior in the offspring. (AU)

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VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVARENGA, TATHIANA A.; FERNANDES, GUILHERME L.; BITTENCOURT, LIA R.; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. The effects of sleep deprivation and obstructive sleep apnea syndrome on male reproductive function: a multi-arm randomised trial. Journal of Sleep Research, v. N/A, p. 15-pg., . (11/12325-6, 12/05396-7)
ALVARENGA, TATHIANA A.; HIROTSU, CAMILA; MAZARO-COSTA, RENATA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Impairment of male reproductive function after sleep deprivation. Fertility and Sterility, v. 103, n. 5, p. 1355+, . (11/12325-6, 12/05396-7, 14/15259-2)
GARCIA, VANESSA ATHAIDE; HIROTSU, CAMILA; MATOS, GABRIELA; ALVARENGA, TATHIANA; PIRES, GABRIEL NATAN; KAPCZINSKI, FLAVIO; SCHROEDER, NADJA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Modafinil ameliorates cognitive deficits induced by maternal separation and sleep deprivation. Behavioural Brain Research, v. 253, p. 274-279, . (11/12325-6, 12/05396-7, 10/15110-8)
ALVARENGA, TATHIANA A.; AGUIAR, MARINA F. P.; MAZARO-COSTA, RENATA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Effects of sleep deprivation during pregnancy on the reproductive capability of the offspring. Fertility and Sterility, v. 100, n. 6, p. 1752-1757, . (11/12325-6, 12/05396-7)
ALVARENGA, TATHIANA A.; MATOS, GABRIELA; SCORZA, FULVIO A.; AMADO, DEBORA; CAVALHEIRO, ESPER A.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Sexual response in female rats with status epilepticus. Epilepsia, v. 54, n. 4, p. 644-648, . (11/12325-6, 12/05396-7, 10/15110-8)
MATOS, GABRIELA; TUFIK, SERGIO; SCORZA, FULVIO A.; CAVALHEIRO, ESPER A.; ANDERSEN, MONICA L.. Sleep and epilepsy: Exploring an intriguing relationship with a translational approach. Epilepsy & Behavior, v. 26, n. 3, p. 405-409, . (12/05396-7, 10/15110-8)
HIROTSU, CAMILA; MATOS, GABRIELA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Changes in gene expression in the frontal cortex of rats with pilocarpine-induced status epilepticus after sleep deprivation. Epilepsy & Behavior, v. 27, n. 2, p. 378-384, . (12/05396-7, 10/15110-8)
MATOS, GABRIELA; TENORIO, NEULI M.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.; CINTRA, FATIMA; TUFIK, SERGIO; ANDERSEN, MONICA L.. More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 44, p. 34-38, . (12/05396-7, 10/15110-8)
MATOS, GABRIELA; SCORZA, FULVIO A.; MAZZOTTI, DIEGO R.; GUINDALINI, CAMILA; CAVALHEIRO, ESPER A.; TUFIK, SERGIO; ANDERSEN, MONICA L.. The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 51, p. 159-165, . (12/05396-7, 10/15110-8)

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