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Surgical antibacterial prophylaxis in patients undergoing liver transplantation: systematic review of randomized clinical trials

Grant number: 12/04955-2
Support Opportunities:Regular Research Grants
Duration: June 01, 2012 - May 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ricardo Augusto Monteiro de Barros Almeida
Grantee:Ricardo Augusto Monteiro de Barros Almeida
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated researchers:Anna Kim ; Claudia Nishida Hasimoto ; Erica Nishida Hasimoto


Surgical site infection (ISS) is an important complication of liver transplantation and remains a major cause of morbidity and mortality. Suitable antibacterial prophylaxis is an essential tool to reduce the incidence of ISS, but the literature seems to lack the best evidence on this subject. The research project will be conducted at the Department of Tropical Diseases and Imaging Diagnosis, Botucatu School of Medicine/UNESP - Botucatu-SP. A systematic review of the literature will be performed in accordance to the Cochrane methodology and aim to map all the clinical trials identified in the main database to assess efficacy and risks of various regimens of antibiotics for antibacterial prophylaxis in patients undergoing liver transplantation. The following databases will be searched: PubMed, CENTRAL (The Cochrane Library), Embase and Lilacs. We will consider randomized controlled trials comparing any scheme of antibacterial agent(s) versus placebo, another antibacterial agent, or a combination of two or more antibacterial agents. We will also consider all the doses, routes of administration (except for enteral route) and duration of prophylactic antibacterial therapy. The data collection and analysis will be performed independently by two reviewers that will select potential studies for inclusion in the review. The title of this systematic review is already registered with the Cochrane Hepato-Biliary Group from the Cochrane Database of Systematic Review journal, with an impact factor of 6.18. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA, RICARDO A. M. B.; HASIMOTO, CLAUDIA N.; KIM, ANNA; HASIMOTO, ERICA N.; EL DIB, REGINA. Antibiotic prophylaxis for surgical site infection in people undergoing liver transplantation. Cochrane Database of Systematic Reviews, n. 12, . (12/04955-2, 12/17820-8)

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