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Calcium score and coronary atherosclerosis in an adult cohort

Grant number: 11/12256-4
Support Opportunities:Regular Research Grants
Duration: June 01, 2012 - May 31, 2014
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Principal Investigator:Paulo Andrade Lotufo
Grantee:Paulo Andrade Lotufo
Host Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The ELSA (Longitudinal Study of Adult Health) is a cohort of 15,105 men and women aged 35 to 74-years-age in six centers, in Brazil, with 5061 of them in São Paulo, addressing risk factors for cardiovascular disease and type 2 diabetes. The baseline finished up December 2012. All participants answered questionnaires and they were underwent exams for subclinical atherosclerosis. The ELSA-Brazil in the coming years will provide new information on the incidence of diabetes and hypertension. Later, it will provide the relative risk for cardiovascular diseases from different exposures variables. Coronary Artery Calcium Score (CACS) has been applied only in three cohorts, and the results improved the 10-year risk of coronary event according to Framingham Heart Study classification by reducing the proportion of individuals classified as "intermediate risk". The proposal will be to perform in the ELSA-Sao Paulo, CACS for all 5,061 people, and additionally an evaluation by a tomography coronary equipment with 64 channels of coronary arteries of over 55 years or younger but a 10-year risk of coronary event exceeding 10% according to Framingham risk score. This project will utilize all the available structure of the ELSA project and the HU-USP. We are applying for support of image storage hardware and material to perform angiography study. This project was approved by the Internal Review Board that considered an adequate risk assessment of contrast and radiation to the participants of the sample that will be under angiotomography scanning, since CACS is a low-risk procedure (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEIXOTO DE MIRANDA, ERIQUE JOSE F.; BITTENCOURT, MARCIO SOMMER; STANIAK, HENRIQUE LANE; PEREIRA, ALEXANDRE C.; FOPPA, MURILO; SANTOS, ITAMAR S.; LOTUFO, PAULO A.; BENSENOR, ISABELA M.. Thyrotrophin levels and coronary artery calcification: Cross-sectional results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). CLINICAL ENDOCRINOLOGY, v. 87, n. 5, p. 597-604, . (11/12256-4)
SANTOS, ITAMAR S.; BITTENCOURT, MARCIO S.; ROCCO, PRISCILA T.; PEREIRA, ALEXANDRE C.; BARRETO, SANDHI M.; BRUNONI, ANDRE R.; GOULART, ALESSANDRA C.; BLAHA, MICHAEL J.; LOTUFO, PAULO A.; BENSENOR, ISABELA M.. Relation of Anxiety and Depressive Symptoms to Coronary Artery Calcium (from the ELSA-Brasil Baseline Data). AMERICAN JOURNAL OF CARDIOLOGY, v. 118, n. 2, p. 183-187, . (11/12256-4)
MIRANDA, ANDREIA M.; STELUTI, JOSIANE; GOULART, ALESSANDRA C.; BENSENOR, ISABELA M.; LOTUFO, PAULO A.; MARCHIONI, DIRCE M.. Coffee Consumption and Coronary Artery Calcium Score: Cross-Sectional Results of ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 7, n. 7, . (14/04540-2, 11/12256-4)
HARADA, PAULO H.; BENSENOR, ISABELA M.; BITTENCOURT, MARCIO S.; NASIR, KHURRAM; BLAHA, MICHAEL J.; JONES, STEVEN R.; TOTH, PETER R.; LOTUFO, PAULO A.. Composite acute phase glycoproteins with coronary artery calcification depends on metabolic syndrome presence - The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). JOURNAL OF CARDIOLOGY, v. 73, n. 5, p. 408-415, . (11/12256-4)
ANDRADE, GUSTAVO R. G.; GORGULHO, BARTIRA; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; MARCHIONI, DIRCE M.. Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study. NUTRIENTS, v. 10, n. 6, . (16/22077-3, 11/12256-4)
CACAU, LEANDRO TEIXEIRA; DE CARLI, EDUARDO; DE CARVALHO, ALINE MARTINS; LOTUFO, PAULO ANDRADE; MORENO, LUIS A.; BENSENOR, ISABELA MARTINS; MARCHIONI, DIRCE MARIA. Development and Validation of an Index Based on EAT-Lancet Recommendations: The Planetary Health Diet Index. NUTRIENTS, v. 13, n. 5, . (11/12256-4, 19/13424-0)
MIRANDA, ANDREIA MACHADO; GOULART, ALESSANDRA C.; BENSENOR, ISABELA M.; LOTUFO, PAULO A.; MARCHIONI, DIRCE MARIA. Coffee consumption and risk of hypertension: A prospective analysis in the cohort study. Clinical Nutrition, v. 40, n. 2, p. 542-549, . (18/04116-7, 11/12256-4)
CACAU, LEANDRO TEIXEIRA; BENSENOR, ISABELA MARTINS; GOULART, ALESSANDRA CARVALHO; CARDOSO, LETICIA OLIVEIRA; LOTUFO, PAULO ANDRADE; MORENO, LUIS A.; MARCHIONI, DIRCE MARIA. Adherence to the Planetary Health Diet Index and Obesity Indicators in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). NUTRIENTS, v. 13, n. 11, . (11/12256-4, 19/13424-0, 20/12326-1)

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