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Genomic study of feed intake and efficiency in Nellore cattle

Grant number: 12/02039-9
Support Opportunities:Regular Research Grants
Duration: May 01, 2012 - April 30, 2014
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:José Bento Sterman Ferraz
Grantee:José Bento Sterman Ferraz
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Abstract

Advances in genetics and molecular biology have made possible the complete sequencing of bovine genome, as well as they opened a new range on this research area. Nowadays, the most used tool in the evaluation of genomic data for beef production is the identification of the single nucleotide polymorphisms (SNP). Many SNP have been identified in Bos taurus in several genes related to weight gain, carcass traits, feed efficiency and other traits, while in Bos indicus there are few studies involving thousands of SNP associated with production traits, specially feed efficiency and feed intake. This project aimed to verify SNP in cattle's genome, associate these with feed intake and feed efficiency and estimate the molecular breeding value of Nellore cattle, the most expressive and important breed under Brazilian cattle. Data already collected on feed intake and feed efficiency of 400 Nellore bulls will be used. These animals had their genomic ADN extracted and will be individually genotyped by commercial chips (BovineHD and BovineSNP50 Beadchip®, Illumina Inc). These genomic data will be used in conjunction with the phenotypic data to characterize the SNP, to calculate gene and genotypic frequencies, additive, allele substitution and dominance effects. In addition, pedigree data will be included to estimate the molecular breeding value of each animal using GBLUP and Bayesian (Bayes A, B, C, CÀ and Lasso) methods. (AU)

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Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTANA, M. H. A.; UTSUNOMIYA, Y. T.; NEVES, H. H. R.; GOMES, R. C.; GARCIA, J. F.; FUKUMASU, H.; SILVA, S. L.; LEME, P. R.; COUTINHO, L. L.; ELER, J. P.; et al. Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus). JOURNAL OF ANIMAL BREEDING AND GENETICS, v. 131, n. 3, p. 210-216, . (12/03551-5, 11/16643-2, 12/02039-9)
SANTANA, M. H. A.; GOMES, R. C.; OZAWA, G. M.; FUKUMASU, H.; SILVA, S. L.; LEME, P. R.; ROSSI JUNIOR, P.; PIRES, P. R. L.; ALEXANDRE, P. A.; OLIVEIRA, P. S.; et al. Single nucleotide polymorphisms in genes linked to ion transport and regulation of appetite and their associations with weight gain, feed efficiency and intake of Nellore cattle. LIVESTOCK SCIENCE, v. 165, p. 33-36, . (12/03551-5, 12/02039-9)
DE ALMEIDA SANTANA, MIGUEL HENRIQUE; OLIVEIRA JUNIOR, GERSON ANTONIO; MELLO CESAR, ALINE SILVA; FREUA, MATEUS CASTELANI; GOMES, RODRIGO DA COSTA; DA LUZ E SILVA, SAULO; LEME, PAULO ROBERTO; FUKUMASU, HEIDGE; CARVALHO, MINOS ESPERANDIO; VENTURA, RICARDO VIEIRA; et al. Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle. JOURNAL OF APPLIED GENETICS, v. 57, n. 4, p. 495-504, . (12/02039-9, 13/20571-2, 14/14121-7)
SANTANA, M. H. A.; OLIVEIRA JUNIOR, G. A.; GOMES, R. C.; SILVA, S. L.; LEME, P. R.; STELLA, T. R.; MATTOS, E. C.; ROSSI JUNIOR, P.; BALDI, F. S.; ELER, J. P.; et al. Genetic parameter estimates for feed efficiency and dry matter intake and their association with growth and carcass traits in Nellore cattle. LIVESTOCK SCIENCE, v. 167, p. 80-85, . (12/03551-5, 12/02039-9)
DE ALMEIDA SANTANA, MIGUEL HENRIQUE; GEBIM POLIZEL, GUILHERME HENRIQUE; GRIGOLETTO, LAIS; FERNANDES, ARICIA CHRISTOFARO; BONIN, MARINA DE NADAI; GOMES, RODRIGO DA COSTA; CARVALHO, MINOS ESPERANDIO; DA LUZ E SILVA, SAULO; LEME, PAULO ROBERTO; ROSSI JUNIOR, PAULO; et al. The genetic and genomic effects of Nellore lineages on feed efficiency, intake and performance. LIVESTOCK SCIENCE, v. 228, p. 104-108, . (13/20571-2, 13/26902-0, 14/07566-2, 12/02039-9)
SANTANA, M. H. A.; GOMES, R. C.; UTSUNOMIYA, Y. T.; NEVES, H. H. R.; NOVAIS, F. J.; BONIN, M. N.; FUKUMASU, H.; GARCIA, J. F.; ALEXANDRE, P. A.; OLIVEIRA JUNIOR, G. A.; et al. Genome-wide association with residual body weight gain in Bos indicus cattle. Genetics and Molecular Research, v. 14, n. 2, p. 5229-5233, . (13/20571-2, 12/02039-9)
FREUA, MATEUS CASTELANI; DE ALMEIDA SANTANA, MIGUEL HENRIQUE; VENTURA, RICARDO VIEIRA; TEDESCHI, LUIS ORLINDO; STERMAN FERRAZ, JOSE BENTO. Using a system of differential equations that models cattle growth to uncover the genetic basis of complex traits. JOURNAL OF APPLIED GENETICS, v. 58, n. 3, p. 393-400, . (13/26902-0, 13/20571-2, 14/07566-2, 12/02039-9)
GEBIM POLIZEL, GUILHERME HENRIQUE; GRIGOLETTO, LAIS; CARVALHO, MINOS ESPERANDIO; ROSSI JUNIOR, PAULO; STERMAN FERRAZ, JOSE BENTO; DE ALMEIDA SANTANA, MIGUEL HENRIQUE. Genetic correlations and heritability estimates for dry matter intake, weight gain and feed efficiency of Nellore cattle in feedlot. LIVESTOCK SCIENCE, v. 214, p. 209-210, . (13/26902-0, 13/20571-2, 14/07566-2, 12/02039-9)
SANTANA, M. H. A.; VENTURA, R. V.; UTSUNOMIYA, Y. T.; NEVES, H. H. R.; ALEXANDRE, P. A.; OLIVEIRA JUNIOR, G. A.; GOMES, R. C.; BONIN, M. N.; COUTINHO, L. L.; GARCIA, J. F.; et al. A genomewide association mapping study using ultrasound-scanned information identifies potential genomic regions and candidate genes affecting carcass traits in Nellore cattle. JOURNAL OF ANIMAL BREEDING AND GENETICS, v. 132, n. 6, p. 420-427, . (14/14121-7, 13/20571-2, 12/02039-9)
GRIGOLETTO, L.; PEREZ, B. C.; SANTANA, M. H. A.; BALDI, F.; FERRAZ, J. B. S.. Genetic contribution of cytoplasmic lineage effect on feed efficiency in Nellore cattle. LIVESTOCK SCIENCE, v. 198, p. 52-57, . (13/20571-2, 14/07566-2, 12/02039-9)
FREUA, MATEUS CASTELANI; DE ALMEIDA SANTANA, MIGUEL HENRIQUE; STERMAN FERRAZ, JOSE BENTO. A new approach for applied nutritional models: Computing parameters of dynamic mechanistic growth models using genorne-wide prediction. LIVESTOCK SCIENCE, v. 190, p. 131-135, . (13/26902-0, 13/20571-2, 14/07566-2, 12/02039-9)
SANTANA, MIGUEL H. A.; UTSUNOMIYA, YURI T.; NEVES, HAROLDO H. R.; GOMES, RODRIGO C.; GARCIA, JOSE F.; FUKUMASU, HEIDGE; SILVA, SAULO L.; OLIVEIRA JUNIOR, GERSON A.; ALEXANDRE, PAMELA A.; LEME, PAULO R.; et al. Genome-wide association analysis of feed intake and residual feed intake in Nellore cattle. BMC GENETICS, v. 15, . (12/03551-5, 11/16643-2, 12/02039-9)
SANTANA, M. H. A.; FREUA, M. C.; DO, D. N.; VENTURA, R. V.; KADARMIDEEN, H. N.; FERRAZ, J. B. S.. Systems genetics and genome-wide association approaches for analysis of feed intake, feed efficiency, and performance in beef cattle. Genetics and Molecular Research, v. 15, n. 4, . (13/20571-2, 12/02039-9, 14/14121-7, 13/26902-0, 14/07566-2)

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