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Studies of the mechanisms of adhesion and cytokine modulation during interaction of epithelial cells and pathogenic fungi

Grant number: 11/22773-6
Support Opportunities:Regular Research Grants
Duration: April 01, 2012 - September 30, 2014
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Erika Suzuki de Toledo
Grantee:Erika Suzuki de Toledo
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Several studies about interaction of fungi of medical importance with host were performed using myeloid cells, which include macrophages, dendritic cells and neutrophils. By acting as structural barrier, lung epithelial cells constitute one of the first mechanisms of defense against inhaled particles and microorganisms. Besides, several groups have demonstrated that bacteria, fungi and other stimuli promote the expression of cytokines, chemokines and receptors in epithelial cells from different sources. Therefore, epithelial cells may participate in innate immunity, modulating host inflammatory response.The importance of epithelial cells in Candida albicans infection is more evident today. On the other hand, studies about interaction of epithelial cells with Paracoccidioides brasiliensis or Histoplasma capsulatum are still incipient. In this manner, the goals of this project are: i) analysis of the involved mechanisms in cytokine secretion by human epithelial cells, during infection with yeasts of P. brasiliensis or H. capsulatum; ii) characterization of proteases, isolated from P. brasiliensis, that degrade interleukin (IL)-6 and IL-8; and, iii) analysis of the mechanisms of adhesion and/or invasion of H. capsulatum yeasts in human epithelial cells. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, PRISCILA; JULIANO, MARIA APARECIDA; TANAKA, APARECIDA SADAE; CARMONA, ADRIANA KARAOGLANOVIC; BATISTA DOS SANTOS, SAARA MARIA; SILVA CAMPITELLI DE BARROS, BIANCA CARLA; MAZA, PALOMA KOREHISA; PUCCIA, ROSANA; SUZUKI, ERIKA. Paracoccidioides brasiliensis induces cytokine secretion in epithelial cells in a protease-activated receptor-dependent (PAR) manner. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, v. 206, n. 2, p. 149-156, . (11/23096-8, 11/22773-6, 15/25652-6)
BARROS, BIANCA C. S. C.; MAZA, PALOMA K.; ALCANTARA, CRISTIANE; SUZUKI, ERIKA. Paracoccidioides brasiliensis induces recruitment of alpha 3 and alpha 5 integrins into epithelial cell membrane rafts, leading to cytokine secretion. Microbes and Infection, v. 18, n. 1, p. 68-77, . (11/22773-6)
ALCANTARA, CRISTIANE; MAZA, PALOMA KOREHISA; SILVA, BIANCA CARLA; BARROS, CAMPITELLI; SUZUKI, ERIKA. Role of protein kinase C in cytokine secretion by lung epithelial cells during infection with Paracoccidioides brasiliensis. PATHOGENS AND DISEASE, v. 73, n. 7, . (11/22773-6)
MAZA, PALOMA K.; BONFIM-MELO, ALEXIS; PADOVAN, ANA C. B.; MORTARA, RENATO A.; ORIKAZA, CRISTINA M.; DAMAS RAMOS, LILIAN M.; MOURA, TAUANY R.; SORIANI, FREDERICO M.; ALMEIDA, RICARDO S.; SUZUKI, ERIKA; et al. Candida albicans: The Ability to Invade Epithelial Cells and Survive under Oxidative Stress Is Unlinked to Hyphal Length. FRONTIERS IN MICROBIOLOGY, v. 8, . (15/25652-6, 11/22773-6)

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