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Natural Killer cell-mediated targeting of human ovarian cancer and possibilities for immunotherapy

Grant number: 11/14520-0
Support Opportunities:Regular Research Grants
Duration: April 01, 2012 - March 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Guimarães
Grantee:Fernando Guimarães
Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Carlos Alberto Petta ; Sophie Françoise Mauricette Derchain

Abstract

We have shown recently the possibility of generating effector cell preparations enriched with CD56+ lymphocytes, NK and NKT-like, by ex vivo expansion of peripheral blood mononuclear cells (PBMC) from patients with ovarian cancer (FAPESP 2006/04900-2). The current project proposes to evaluate the receptor repertoire (inhibitory receptors: KIR2DL1, KIR2DL2/3 and KIR3DL1 and activating receptors: NKp30, NKp44, NKp46, NKG2D and DNAM-1) and functional integrity (CD107a molecule expression and cytotoxicity against primary neoplasm cells) of the NK and NKT-like lymphocytes from patients with ovarian neoplasm, before and after the ex vivo expansion of CD56+ cells. The experimental design will allow the evaluation of effector cell subtypes independently, and to take into account the clinical stage of the subjects. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, RODRIGO FERNANDES; PETTA, CARLOS ALBERTO; DERCHAIN, SOPHIE FRANCOISE; ALICI, EVREN; GUIMARAES, FERNANDO. Up-regulation of DNAM-1 and NKp30, associated with improvement of NK cells activation after long-term culture of mononuclear cells from patients with ovarian neoplasia. HUMAN IMMUNOLOGY, v. 75, n. 8, p. 777-784, . (11/14520-0, 10/17202-7)
DA SILVA, RODRIGO FERNANDES; CARDOZO, DANIELA MAIRA; LIBANIO RODRIGUES, GISELE OLINTO; DE SOUZA-ARAUJO, CAROLINE NATANIA; MIGITA, NATACHA AZUSSA; LUCCI DE ANGELO ANDRADE, LILIANA APARECIDA; DERCHAIN, SOPHIE; YUNES, JOSE ANDRES; GUIMARAES, FERNANDO. CAISMOV24, a new human low-grade serous ovarian carcinoma cell line. BMC CANCER, v. 17, . (11/14520-0, 16/07822-4, 14/07401-3, 12/12802-1)

Please report errors in scientific publications list by writing to: gei-bv@fapesp.br.