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Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response

Abstract

Recent studies have demonstrated the existence of a complex and elaborate bidirectional communication between the nervous and immune systems. The recent discovered "cholinergic antiinflammatory pathway" (CAP) has received great attention because it is involved in the maintenance of homeostatic immunity. However, due to the complexity of CAP, since it involves many areas of science (immunology, pharmacology, physiology, anatomy and neurology) , there are few groups investigating (i) the mechanisms by which CAP controls the immune responses and (ii) how the use of this knowledgement could be applied in the modulation of immune responses that are involved in inflammatory diseases. Therefore, the aim of this project is to propose a new research area about neuroimmunology/neuroimmunomodulation in Brazil, aiming to understand the functional importance of neuro-immune axis in the innate, adaptive Th1 and Th2 immune responses, which are altered in sepsis, arthritis and asthma, respectively. Based on the fact that immune cells express receptors for neurotransmitters and they are considered important sources of non-neural neurotransmitters, we will use pharmacological and/or surgical tools to alter the neuro-immune axis (with emphasis on CAP) and to investigate its effect on the innate and adaptive Th1/Th2 immune responses, using animal models of the diseases mentioned above. The understanding of this neuro-immune communication may be used in the discovery of new therapeutic targets and in the treatment for diseases involving the immune system, such as infections and chronic inflammatory diseases (autoimmune diseases). (AU)

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Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BASSI, G. S.; KANASHIRO, A.; RODRIGUES, G. J.; CUNHA, F. Q.; COIMBRA, N. C.; ULLOA, L.. Brain Stimulation Differentially Modulates Nociception and Inflammation in Aversive and Non-aversive Behavioral Conditions. Neuroscience, v. 383, p. 191-204, . (11/20343-4, 13/08216-2, 13/20549-7, 12/04237-2)
SILVA, RANGEL L.; CASTANHEIRA, FERNANDA V.; FIGUEIREDO, JOZI G.; BASSI, GABRIEL S.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; KANASHIRO, ALEXANDRE. Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen. Inflammation, v. 39, n. 4, p. 1405-1413, . (13/01466-3, 12/04237-2, 11/20343-4, 11/19670-0, 13/08216-2)
BASSI, GABRIEL SHIMIZU; ULLOA, LUIS; SANTOS, VICTOR RODRIGUES; DEL VECCHIO, FLAVIO; DELFINO-PEREIRA, POLIANNA; RODRIGUES, GERSON JHONATAN; CASTANIA, JACI AIRTON; CUNHA, FERNANDO DE QUEIROZ; SALGADO, HELIO CESAR; CUNHA, THIAGO MATTAR; et al. Cortical stimulation in conscious rats controls joint inflammation. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 84, n. A, p. 201-213, . (13/20549-7, 12/04237-2, 11/20343-4, 13/08216-2)
KANASHIRO, ALEXANDRE; FRANCHIN, MARCELO; BASSI, GABRIEL SHIMIZU; REIS SANTANA, DENIS AUGUSTO; CUNHA, THIAGO MATTAR; CUNHA, FERNANDO QUEIROZ; ULLOA, LUIS; RODRIGUES, GERSON JONATHAN. Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 32, n. 2, p. 155-162, . (11/20343-4, 13/08216-2, 12/04237-2)
BASSI, GABRIEL S.; MALVAR, DAVID DO C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; KANASHIRO, ALEXANDRE. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 389, n. 8, p. 851-861, . (11/20343-4, 13/08216-2, 11/19670-0, 12/04237-2)
SCHNEIDER, AYDA HENRIQUES; KANASHIRO, ALEXANDRE; VELOSO DUTRA, SABRINA GRAZIANI; DE SOUZA, RAQUEL DO NASCIMENTO; VERAS, FLAVIO PROTASIO; CUNHA, FERNANDO DE QUEIROZ; ULLOA, LUIS; MECAWI, ANDRE SOUZA; REIS, LUIS CARLOS; MALVARA, DAVID DO CARMO. Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice. International Immunopharmacology, v. 72, p. 504-510, . (11/20343-4, 13/08216-2, 12/04237-2)
PASSAGLIA, PATRICIA; DE LIMA FAIM, FELIPE; BATALHAO, MARCELO EDUARDO; STABILE, ANGELITA MARIA; BENDHACK, LUSIANE MARIA; ANTUNES-RODRIGUES, JOSE; LACCHINI, RICCARDO; CAPELLARI CARNIO, EVELIN. Central Administration of Angiotensin-(1-7) Improves Vasopressin Impairment and Hypotensive Response in Experimental Endotoxemia. CELLS, v. 10, n. 1, . (14/22477-6, 11/20343-4, 15/09857-7)
KUSUDA, RICARDO; CARREIRA, ELEONORA UCHOA; ULLOA, LUIS; CUNHA, FERNANDO QUEIROZ; KANASHIRO, ALEXANDRE; CUNHA, THIAGO MATTAR. Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway. Brain Research, v. 1727, . (12/23846-0, 13/08216-2, 11/20343-4, 10/16823-8)
KANASHIRO, ALEXANDRE; DE LUCENA LEONCIO, THAIS OLIVEIRA; SCHNEIDER, AYDA HENRIQUES; ALVES, HELIO ROCHA; BASSI, GABRIEL SHIMIZU; VELOSO DUTRA, SABRINA GRAZIANI; CUNHA, FERNANDO DE QUEIROZ; ULLOA, LUIS; MALVAR, DAVID DO CARMO. Regulation of murine arthritis by systemic, spinal, and intra-articular adrenoceptors. PHARMACOLOGICAL REPORTS, v. 71, n. 6, p. 1095-1103, . (11/20343-4, 13/08216-2, 12/04237-2)
KANASHIRO, ALEXANDRE; HIROKI, CARLOS HIROJI; DA FONSECA, DENISE MORAIS; BIRBRAIR, ALEXANDER; FERREIRA, RAPHAEL GOMES; BASSI, GABRIEL SHIMIZU; FONSECA, MIRIAN D.; KUSUDA, RICARDO; MARTELOSSI CEBINELLI, GUILHERME CESAR; DA SILVA, KATIUSSIA PINHO; et al. The role of neutrophils in neuro-immune modulation. PHARMACOLOGICAL RESEARCH, v. 151, . (12/04237-2, 11/20343-4, 16/08385-7, 11/19670-0, 13/08216-2)
BROGNARA, FERNANDA; CASTANIA, JACI A.; DIAS, DANIEL P. M.; LOPES, ALEXANDRE H.; FAZAN, JR., RUBENS; KANASHIRO, ALEXANDRE; ULLOA, LUIS; SALGADO, HELIO C.. Baroreflex stimulation attenuates central but not peripheral inflammation in conscious endotoxemic rats. Brain Research, v. 1682, p. 54-60, . (11/20343-4, 13/20549-7, 14/15386-4, 17/05163-6)
JOSEPH, BIJU; SHIMOJO, GUILHERME; LI, ZHIFENG; DEL ROCIO THOMPSON-BONILLA, MARIA; SHAH, ROSHAN; KANASHIRO, ALEXANDRE; SALGADO, HELIO C.; ULLOA, LUIS. Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice. SCIENTIFIC REPORTS, v. 9, . (11/20343-4)
SANTOS-ALMEIDA, FERNANDA MACHADO; DOMINGOS-SOUZA, GEAN; MESCHIARI, CESAR A.; FAVARO, LAURA CAMPOS; BECARI, CHRISTIANE; CASTANIA, JACI A.; LOPES, ALEXANDRE; CUNHA, THIAGO M.; MORAES, DAVI J. A.; CUNHA, FERNANDO Q.; et al. Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation. SCIENTIFIC REPORTS, v. 7, . (13/20549-7, 13/06452-0, 11/20343-4, 13/26217-6, 13/13269-8)
KANASHIRO, ALEXANDRE; SONEGO, FABIANE; FERREIRA, RAPHAEL G.; CASTANHEIRA, FERNANDA V. S.; LEITE, CAIO A.; BORGES, VANESSA F.; NASCIMENTO, DANIELE C.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; ULLOA, LUIS; et al. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. PHARMACOLOGICAL RESEARCH, v. 117, p. 1-8, . (11/20343-4, 13/08216-2, 11/19670-0, 12/04237-2)
DAS GRACAS CORSI-ZUELLI, FABIANA MARIA; BROGNARA, FERNANDA; DA SILVA QUIRINO, GUSTAVO FERNANDO; HIROKI, CARLOS HIROJI; FAIS, RAFAEL SOBRANO; DEL-BEN, CRISTINA MARTA; ULLOA, LUIS; SALGADO, HELIO CESAR; KANASHIRO, ALEXANDRE; LOUREIRO, CAMILA MARCELINO. Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Acetylcholine the Alpha-7 nicotinic Acetylcholine Receptor. FRONTIERS IN IMMUNOLOGY, v. 8, . (13/20549-7, 16/12195-9, 11/20343-4, 15/10378-6, 16/07641-0, 16/11988-5, 12/05178-0)
BASSI, GABRIEL SHIMIZU; MARTINS DIAS, DANIEL PENTEADO; FRANCHIN, MARCELO; TALBOT, JHIMMY; REIS, DANIEL GUSTAVO; MENEZES, GUSTAVO BATISTA; CASTANIA, JACI AIRTON; GARCIA-CAIRASCO, NORBERTO; MORAES RESSTEL, LEONARDO BARBOSA; SALGADO, HELIO CESAR; et al. Modulation of experimental arthritis by vagal sensory and central brain stimulation. BRAIN BEHAVIOR AND IMMUNITY, v. 64, p. 330-343, . (13/20549-7, 12/04237-2, 11/20343-4, 15/20463-0, 13/08216-2)
BROGNARA, FERNANDA; CASTANIA, JACI AIRTON; MARTINS DIAS, DANIEL PENTEADO; KANASHIRO, ALEXANDRE; SALGADO, HELIO CESAR. Time Course of Hemodynamic Responses to Different Doses of Lipopolysaccharide in Unanesthetized Male Rats. FRONTIERS IN PHYSIOLOGY, v. 10, . (11/20343-4, 17/05163-6, 13/20549-7)
BASSI, GABRIEL S.; BROGNARA, FERNANDA; CASTANIA, JACI A.; TALBOT, JHIMMY; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; ULLOA, LUIS; KANASHIRO, ALEXANDRE; MARTINS DIAS, DANIEL P.; SALGADO, HELIO C.. Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function. BRAIN BEHAVIOR AND IMMUNITY, v. 49, p. 140-147, . (13/20549-7, 12/04237-2, 11/20343-4, 13/08216-2, 14/15386-4)
FIGUEIREDO, JOZI; FERREIRA, ANA ELISA; SILVA, RANGEL LEAL; ULLOA, LUIS; GRIECO, PAOLO; CUNHA, THIAGO MATTAR; FERREIRA, SERGIO HENRIQUE; CUNHA, FERNANDO DE QUEIROZ; KANASHIRO, ALEXANDRE. NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 386, n. 4, p. 311-318, . (11/20343-4, 12/04237-2, 11/11931-0)
PASSAGLIA, PATRICIA; FAIM, FELIPE DE LIMA; BATALHAO, MARCELO EDUARDO; BENDHACK, LUSIANE MARIA; ANTUNES-RODRIGUES, JOSE; ULLOA, LUIS; KANASHIRO, ALEXANDRE; CARNIO, EVELIN CAPELLARI. Central angiotensin-(1-7) attenuates systemic inflammation via activation of sympathetic signaling in endotoxemic rats. BRAIN BEHAVIOR AND IMMUNITY, v. 88, p. 606-618, . (11/20343-4, 15/09857-7, 14/22477-6)

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