This project proposes the study and development of a multisensory system (MS) for the non-invasive detection of chemical species, both at liquid and gaseous phases, related to diabetes, lung cancer, tuberculosis, and so on. Sick subjects exhale chemicals through breath and sweat which are related to particular metabolic process of a certain type of disease. Such chemicals could be precisely detected and quantified but the lack of an appropriate instrumentation such chemicals are not considered during the patient evaluation. Therefore, a biomedical instrumentation capable of performing this task should contribute to accomplish rapid and reliable diagnosis of diseases in sub-clinic level. The proposed MS offers distinguished features including low cost, operation at room temperature and a hybrid configuration of sensors (non-specific and specific sensors) interrogated under AC stimulus which imparts higher sensitivity and greater analytes discrimination capabilities. Non-specific sensors will be based on nanostructured films of semiconducting polymers, phthalocyanines, carbon nanotubes and inorganic nanoparticles whereas specific sensors will be produced by molecular imprinting techniques within polymeric and inorganic films. In this project, the electrical response of the MS, in vitro, in AC regime will be registered in the presence of acetone, alkanes (butane, hexane and 2-methylhexane) and 1-methylnaphthalene which are recognized as biomarkers of diabetes, lung cancer and lung tuberculosis, respectively. The responses will be further processed by multivariate data analysis tools. The detection properties, namely sensitivity, selectivity, detection limit and reset time will be investigated as a function of temperature and relative humidity. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
PINHEIRO DA SILVA, MAURO FRANCISCO;
DE OLIVEIRA, DEBORA ROSE;
CAVALLARI, MARCO ROBERTO;
TADEU DIRANI, ELY ANTONIO;
TRIBONI, EDUARDO REZENDE;
PATERNO, LEONARDO GIORDANO;
FONSECA, FERNANDO JOSEPETTI;
ANDO, ROMULO AUGUSTO;
BAPTISTA, MAURICIO DA SILVA;
POLITI, MARIO JOSE;
ISOLANI, PAULO CELSO;
BERNARDO LENZ E SILVA, GUILHERME FREDERICO.
A simple visible light photo-assisted method for assembling and curing multilayer GO thin films.
Materials Chemistry and Physics,
SEP 1 2015.
Web of Science Citations: 2.