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Periodontal treatment and metabolic control in type 2 Diabetic patients

Grant number: 11/06982-4
Support Opportunities:Regular Research Grants
Duration: February 01, 2012 - January 31, 2015
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Giuseppe Alexandre Romito
Grantee:Giuseppe Alexandre Romito
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The literature have not established the mechanisms linking inflammatory periodontal diseases and diabetes mellitus type 2 (DMT2). This study aims to evaluate the impact of periodontal therapy on glycemic control in patients with T2DM. This study is a randomized clinical trial with 120 DMT2 patients sample. Individuals will be divided into two groups two and receive two different forms of periodontal treatment. One group will receive intensive periodontal therapy (IPT) and the other, supragingival periodontal therapy (TPS). Blood sample for glucose analysis will be collected to evaluate the glycated hemoglobin (HbA1c), advanced glycation end product (carboxymethyl-lysine), and some inflammatory biomarkers, such as inflammatory biomarker tumor necrosis factor alpha (TNF-±), C-reactive protein (CRP), leucocyte count, interleukin 6 (il-6) and interleukin 1 ± and ². The analysis will be made at baseline, after two, six and twelve months of the end of periodontal treatment. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola Tanerella forsythia will also be analyzed at the same times described, just to evaluate the effectiveness of periodontal treatment. During the study, diet questionnaires will be used in order to better control and avoid a possible bias. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RABELO, MARIANA DE SOUSA; GOMES, GIOVANE HISSE; FOZ, ADRIANA MOURA; STADLER, AMANDA FINGER; CUTLER, CHRISTOPHER W.; SUSIN, CRISTIANO; ROMITO, GIUSEPPE ALEXANDRE. Short-term effect of non-surgical periodontal treatment on local and systemic cytokine levels: Role of hyperglycemia. CYTOKINE, v. 138, . (11/06982-4)
CARILLO ARTESE, HILANA PAULA; LONGO, PRISCILA LARCHER; GOMES, GIOVANE HISSE; ALVES MAYER, MARCIA PINTO; ROMITO, GIUSEPPE ALEXANDRE. Supragingival biofilm control and systemic inflammation in patients with type 2 diabetes mellitus. Brazilian Oral Research, v. 29, n. 1, . (11/06982-4)
RABELO, MARIANA DE SOUSA; EL-AWADY, AHMED; MOURA FOZ, ADRIANA; HISSE GOMES, GIOVANE; RAJENDRAN, MYTHILPRIYA; MEGHIL, MOHAMED M.; LOWRY, SCOTT; ROMITO, GIUSEPPE ALEXANDRE; CUTLER, CHRISTOPHER W.; SUSIN, CRISTIANO. Influence of T2DM and prediabetes on blood DC subsets and function in subjects with periodontitis. ORAL DISEASES, v. 25, n. 8, p. 2020-2029, . (11/06982-4)

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