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The effect of low level laser therapy, topical antiinflammatory drug and exercise in the treatment of papain-induced knee osteoarthritis in rats

Grant number: 11/18330-1
Support Opportunities:Regular Research Grants
Duration: December 01, 2011 - February 28, 2014
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Rodrigo Alvaro Brandão Lopes Martins
Grantee:Rodrigo Alvaro Brandão Lopes Martins
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Osteoarthritis (OA) is a disease that commonly affects humans and is characterized as a degenerative process that covers the joints. OA affects the articular cartilage, subchondral bone, ligaments, joint capsule, synovial membrane and periarticular muscles. The treatment for this disorder is based on pharmacological therapy, surgical and non-pharmacological, alone or in combination, to maximize the beneficial effects and minimize side effects. This research project aims to evaluate and compare the effects of pharmacological therapy with nonsteroidal anti-inflammatory drug (NSAID) for topical use, the effects of physical activity and finally to the low power laser therapy (LBP) in an experimental model osteoarthritis. The OA will be induced by an intra-articular injection of papain in the right knee of male Wistar rats. After 21 days the animals will be treated with topical NSAID and / or physical activity (swimming) and / or LBP. Treatments will be performed 03 times per week for 03 weeks, a total of nine sessions for swimming and for LBP. The application of topical diclofenac is also carried out, 03 times a week. Will be carried out biochemical and morphological analysis of the knee joint, including radiography, histology, total leukocytes, differentiated activity of myeloperoxidase (MPO), RT-PCR (COX-1, COX-2, IL-1², IL-6 , IL-10, TNF-±, MMP-3 and MMP-13), analysis of cytokines by ELISA (TNF-±, IL-1², IL-6 and IL-10), prostaglandin E2 (PGE2) and Finally, Western-Blott (COX-1 and COX-2). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NATERSTAD, INGVILL FJELL; ROSSI, RAFAEL PAOLO; MARCOS, RODRIGO LABAT; PARIZZOTO, NIVALDO ANTONIO; FRIGO, LUCIO; JOENSEN, JON; LEONARDO LOPES MARTINS, PATRICIA SARDINHA; BJORDAL, JAN MAGNUS; BRANDAO LOPES-MARTINS, RODRIGO ALVARO. Comparison of Photobiomodulation and Anti-Inflammatory Drugs on Tissue Repair on Collagenase-Induced Achilles Tendon Inflammation in Rats. Photomedicine and Laser Surgery, v. 36, n. 3, p. 137-145, . (11/18330-1)
RAMOS, LUCIANO; MARCOS, RODRIGO LABAT; TORRES-SILVA, ROMILDO; PALLOTA, RODNEY CAPP; MAGACHO, TATIANA; PAZELLO MAFRA, FERNANDO FRANCISCO; MACEDO, MICHEL MONTEIRO; DE PAIVA CARVALHO, RODRIGO LEAL; BJORDAL, JAN MAGNUS; LOPES-MARTINS, RODRIGO ALVARO B.. Characterization of Skeletal Muscle Strain Lesion Induced by Stretching in Rats: Effects of Laser Photobiomodulation. Photomedicine and Laser Surgery, v. 36, n. 9, p. 460-467, . (11/18330-1, 13/07276-1)

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