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Development of methods to perform permeation studies of topical formulations for dentistry applications

Grant number: 11/18113-0
Support Opportunities:Regular Research Grants
Duration: March 01, 2012 - February 28, 2014
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Francisco Carlos Groppo
Grantee:Francisco Carlos Groppo
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated researchers:Michelle Franz Montan Braga Leite


Permeation studies in vitro and ex vivo performed in Franz diffusion cells are important during pre-clinical phase of a new developed medication because it is possible to preview how this drug will permeate through the barrier, i.e. mucosal or skin, allowing a pharmacokinetics and a biodisponibility improvement. The literature has shown that permeation studies across oral mucosa are performed using pig esophagus mucosa model. However, this tissue has little or no keratinization being the esophagus a limited model to evaluate the performance of formulations for dentistry use. There are other regions of the mouth with different levels of keratinization (palatal mucosa and gingival) which are also target sites to drugs such as local anesthetics, antimicrobial agents, corticoids, antivirus, etc. The objectives of the present study are: a) development and standardize different barriers to perform permeation studies (in Franz diffusion cells) of topical formulations for dentistry use; b) histological assessment of those barriers; c) to compare permeation of lidocaine across the different barriers in Franz diffusion cells; d) to evaluate freezing effect on the permeability and retention of those tissues. We hope to develop methods that could be useful for permeation studies for drugs used in dentistry, to improve their pharmacokinetic and pharmacodinamic performance. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SERPE, LUCIANO; MUNIZ, BRUNO VILELA; DOS SANTOS, CLEITON PITA; DA SILVA, CAMILA BATISTA; VOLPATO, MARIA CRISTINA; GROPPO, FRANCISCO CARLOS; VIANNA LOPEZ, RENATA FONSECA; FRANZ-MONTAN, MICHELLE. Full-Thickness Intraoral Mucosa Barrier Models for In Vitro Drug-Permeation Studies Using Microneedles. Journal of Pharmaceutical Sciences, v. 108, n. 5, p. 1756-1764, . (12/06974-4, 12/02492-5, 11/18113-0)
FRANZ-MONTAN, MICHELLE; SERPE, LUCIANO; MAIA MARTINELLI, CLAUDIA CRISTINA; DA SILVA, CAMILA BATISTA; DOS SANTOS, CLEITON PITA; NOVAES, PEDRO DUARTE; VOLPATO, MARIA CRISTINA; DE PAULA, ENEIDA; VIANNA LOPEZ, RENATA FONSECA; GROPPO, FRANCISCO CARLOS. Evaluation of different pig oral mucosa sites as permeability barrier models for drug permeation studies. European Journal of Pharmaceutical Sciences, v. 81, p. 52-59, . (11/23475-9, 12/06974-4, 11/18113-0, 14/14457-5)

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