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Preclinical pharmacokinetics of new drugs and pharmaceuticals forms

Abstract

The main factors that hinder the introduction of new drugs on the market have a direct or at least one pharmacokinetic correlated problem. An unfavourable pharmacokinetic profile as low bioavailability, limited volume of distribution or rapid metabolism can determine inefficacy or relevant toxicity. Preclinical pharmacokinetic studies plays a important role predicting the construction of dosing regimens for clinical studies and and have a close relation to pharmacodynamics and toxicodynamics. Thus, these studies are fundamental to the assessment of new drugs prior to their application in clinical trials. In Brazil, there are many research groups focused on new molecules synthesys, characterization and investigation of its therapeutical uses. However, in our contry, preclinical pharmacokinetic researches - essential for future clinical trials - are relatively recent. In this project, we present a proposal to require laboratory equipment and consumables for these pharmacokinetic studies, which includes three subproducts developed by a FCF/UNESP group - a prodrug candidate with anti-inflammatory properties (DICCIC), a potential antichagasic prodrug and a microemulsion system containig doxorubicin. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALONSO, J. M.; PECCININI, R. G.; CAMPOS, M. L.; NITTA, T. Y.; AKUTAGAWA, T. Y. M.; CRESCENCIO, A. P.; ALVES, A. L. G.; RODRIGUES, C. A.; WATANABE, M. J.; HUSSNI, C. A.. Plasma and peritoneal fluid concentrations of ceftriaxone after intravenous and intraperitoneal administration in horses. VETERINARY JOURNAL, v. 234, p. 72-76, . (13/13799-7, 11/11239-9)
CANDIDO, CAROLINE DAMICO; CAMPOS, MICHEL LEANDRO; CORREA VIDIGAL ASSUMPCAO, JULIANA URUGUAY; PESTANA, KELLY CHRYSTINA; PADILHA, ELIAS CARVALHO; CARLOS, IRACILDA ZEPPONE; PECCININI, ROSANGELA GONCALVES. Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin. Journal of Pharmaceutical Sciences, v. 103, n. 10, p. 3297-3301, . (11/11239-9)
DAVANCO, MARCELO GOMES; DE CAMPOS, MICHEL LEANDRO; PECCININI, ROSANGELA GONCALVES. Rapid and sensitive ultra-high-pressure liquid chromatography method for quantification of antichagasic benznidazole in plasma: application in a preclinical pharmacokinetic study. BIOMEDICAL CHROMATOGRAPHY, v. 29, n. 7, p. 1008-1015, . (11/11239-9)
DAVANCO, MARCELO GOMES; CAMPOS AGUIAR, ANNA CAROLINE; DOS SANTOS, LEANDRO ALVES; PADILHA, ELIAS CARVALHO; CAMPOS, MICHEL LEANDRO; DE ANDRADE, CLEVERTON ROBERTO; DA FONSECA, LUIZ MARCOS; DOS SANTOS, JEAN LEANDRO; CHIN, CHUNG MAN; KRETTLI, ANTONIANA URSINE; et al. Evaluation of Antimalarial Activity and Toxicity of a New Primaquine Prodrug. PLoS One, v. 9, n. 8, . (11/11239-9)
CAMPOS, MICHEL LEANDRO; ALONSO, JULIANA DE MOURA; MARTINS, EVELIN DOS SANTOS; OLIVEIRA, JONATA AUGUSTO; HUSSNI, CARLOS ALBERTO; PECCININI, ROSANGELA GONCALVES. Ceftriaxone pharmacokinetics by new simple and sensitive ultra-high-performance liquid chromatography method. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 88, n. 1, p. 95-99, . (11/11239-9)
MARTINS, EVELIN DOS SANTOS; OLIVEIRA, JONATA AUGUSTO; FRANCHIN, TAISA BUSARANHO; ULIAN SILVA, BRUNA CRISTINA; CANDIDO, CAROLINE DAMICO; PECCININI, ROSANGELA GONCALVES. Simple and Rapid Method by Ultra High-Performance Liquid Chromatography (UHPLC) with Ultraviolet Detection for Determination of Efavirenz in Plasma: Application in a Preclinical Pharmacokinetic Study. Journal of Chromatographic Science, v. 57, n. 10, p. 874-880, . (11/11239-9, 15/23843-9)

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