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Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media

Grant number: 11/50318-1
Support Opportunities:Research Projects - Thematic Grants
Duration: September 01, 2011 - November 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Ana Maria da Costa Ferreira
Grantee:Ana Maria da Costa Ferreira
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Helena Maria Petrilli ; Vera Regina Leopoldo Constantino
Associated grant(s):16/50317-9 - Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release, AP.R SPRINT
14/09367-7 - Investigation on the role of metallodrug-carbohydrate interactions in multidrug resistance tumor cells, AV.EXT
Associated scholarship(s):12/22067-7 - Development of electronic and structural biomolecular models for pharmaceutical and medicinal applications, BP.PD
12/24637-5 - Studies on interactions of essential metal complexes and proteasome, BP.IC
12/17671-2 - Investigations on the Biological Activity of Heterodinuclear Complexes based on Copper and Platinum, BP.PD
 + associated scholarships 12/12209-9 - Inorganic carriers of bioactive substances: development, characterization, toxicity evaluation of in vitro delivery and in vivo absorption after oral administration, BP.PD
11/18958-0 - Chelator-peptide conjugates permeable to the blood-brain barrier as protectors against iron-induced toxicity, BP.PD
12/06291-4 - Synthesis and characterization of hybrid materials based on layered double hydroxides and bioactive organic species, BP.IC
12/02326-8 - Computational modeling of solid-molecule interaction in systems with nanotechnology interests, BP.DR - associated scholarships

Abstract

Studies of reactive species in biological systems, implicated in vital or pathological processes are focused in this project. The design, preparation and isolation of those species as free compounds or inserted in suitable inorganic matrices, forming functional materials will be provided. Those species include antioxidant or oxidant compounds, polymers, chelating agents, and respective metal complexes. Their reactivity in processes, where they could act as pharmacological or medicinal agents, will be investigated. Appropriate methodologies for their detection and identification, as well as for their transport, recognition by specific targets and toxicity evaluation will be developed. Experimental data will be rationalized by theoretical calculations, trying to set up or suggest more efficient species. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (50)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FAZZI, RODRIGO B.; FERRAZ DE PAIVA, RAPHAEL E.; DA COSTA FERREIRA, ANA M.. A combined EPR spectroscopy and DFT-based structural interpretation of the antitumor properties of oxindolimine-copper(II) complexes. ARKIVOC, n. 2, p. 123-133, . (11/50318-1, 13/07937-8, 18/21537-6)
GUSTAVO F PEROTTI; THITISILP KIJCHAVENGKUL; RAFAEL A AURAS; VERA R. L CONSTANTINO. Nanocomposites Based on Cassava Starch and Chitosan-Modified Clay: Physico‑Mechanical Properties and Biodegradability in Simulated Compost Soil. Journal of the Brazilian Chemical Society, v. 28, n. 4, p. 649-658, . (11/50318-1)
SILVEIRA, VIVIAN C.; ABBOTT, MARIANA P.; CAVICCHIOLI, MAURICIO; GONCALVES, MARCOS B.; PETRILLI, HELENA M.; DE REZENDE, LEANDRO; AMARAL, ANTONIA T.; FONSECA, DAVID E. P.; CARAMORI, GIOVANNI F.; DA COSTA FERREIRA, ANA M.. Peculiar reactivity of a di-imine copper(II) complex regarding its binding to albumin protein. DALTON TRANSACTIONS, v. 42, n. 18, p. 6386-6396, . (11/50318-1, 05/60596-8)
CUNHA, VANESSA R. R.; IZUMI, CELLY M. S.; PETERSEN, PHILIPPE A. D.; MAGALHAES, ALVICLER; TEMPERINI, MARCIA L. A.; PETRILLI, HELENA M.; CONSTANTINO, VERA R. L.. Mefenamic Acid Anti-Inflammatory Drug: Probing Its Polymorphs by Vibrational (IR and Raman) and Solid-State NMR Spectroscopies. Journal of Physical Chemistry B, v. 118, n. 16, p. 4333-4344, . (11/50318-1, 12/12209-9)
KATKAR, PRAFULLA; COLETTA, ANDREA; CASTELLI, SILVIA; SABINO, GUSTAVO L.; ALVES COUTO, RICARDO A.; DA COSTA FERREIRA, ANA M.; DESIDERI, ALESSANDRO. Effect of oxindolimine copper(II) and zinc(II) complexes on human topoisomerase I activity. METALLOMICS, v. 6, n. 1, p. 117-125, . (11/50318-1, 12/03080-2)
VIEIRA, EDUARDO GUIMARAES; MIGUEL, RODRIGO BERNARDI; DA SILVA, DANIEL RODRIGUES; FAZZI, RODRIGO BONI; ALVES DE COUTO, RICARDO ALEXANDRE; MARIN, JAYR HENRIQUE; ARRUDA TEMPERINI, MARCIA LAUDELINA; SHINOHARA, JORGE DA SILVA; TOMA, HENRIQUE EISI; RUSSO, LILIAN CRISTINA; et al. Functionalized nanoparticles as adjuvant to increase the cytotoxicity of metallodrugs toward tumor cells. NEW JOURNAL OF CHEMISTRY, v. 43, n. 1, p. 386-398, . (11/50318-1, 16/21070-5, 17/21919-3, 16/16735-8, 13/07937-8)
ARNDT, ANDERSON; LIRIA, CLEBER WANDERLEI; YOKOYAMA-YASUNAKA, JENICER K. U.; TERESA MACHINI, M.; BORTOLIN UHANA, SILVIA RENI; ESPOSITO, BRENO PANNIA. New iminodibenzyl derivatives with anti-leishmanial activity. Journal of Inorganic Biochemistry, v. 172, p. 9-15, . (16/03709-9, 11/50318-1)
MIGUEL, RODRIGO BERNARDI; DIVINA PETERSEN, PHILIPPE ALEXANDRE; GONZALES-ZUBIATE, FERNANDO A.; OLIVEIRA, CARLA COLUMBANO; KUMAR, NARESH; DO NASCIMENTO, RAFAEL RODRIGUES; PETRILLI, HELENA MARIA; DA COSTA FERREIRA, ANA MARIA. Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 20, n. 7, p. 1205-1217, . (11/50318-1, 10/51842-3, 13/07937-8)
FERREIRA, MARIANA MENDONCA; BIZETO, MARCOS AUGUSTO. Kinetic analysis of pH influence on the fluorescein release from chitosan-coated mesoporous silica nanoparticles. JOURNAL OF POROUS MATERIALS, v. 27, n. 4, . (11/50318-1, 19/05467-0)
NUNES, CLEIA JUSTINO; OTAKE, ANDREIA HANADA; BUSTOS, SILVINA ODETE; FAZZI, RODRIGO BONI; CHAMMAS, ROGER; DA COSTA FERREIRA, ANA MARIA. Unlike reactivity of mono- and binuclear imine-copper(II) complexes toward melanoma cells via a tyrosinase-dependent mechanism. Chemico-Biological Interactions, v. 311, . (11/50318-1, 13/07937-8)
VIEIRA, ADRIANA PIRES; WEGERMANN, CAMILA ANCHAU; DA COSTA FERREIRA, ANA MARIA. Comparative studies of Schiff base-copper(II) and zinc(II) complexes regarding their DNA binding ability and cytotoxicity against sarcoma cells. NEW JOURNAL OF CHEMISTRY, v. 42, n. 15, p. 13169-13179, . (11/50318-1, 13/07937-8)
COSTA, MARCELA BLOISE; BIZETO, MARCOS AUGUSTO. Synthesis of a highly hydrophobic silica mesostructure by a modified co-condensation procedure and evaluation of its drug release capability. JOURNAL OF POROUS MATERIALS, v. 25, n. 6, p. 1603-1609, . (11/50318-1)
TAVARES ALVES MARTINS, DANIEL OLIVEIRA; FREITAS, RAFAEL SA; DA COSTA FERREIRA, ANA MARIA. Selective CO2 Adsorption at Low Pressure in Nitrogen-Rich Copper(II) Coordination Polymers. CHEMISTRYSELECT, v. 7, n. 31, p. 9-pg., . (11/50318-1, 13/07937-8, 18/21510-0, 17/19071-6)
DE MATOS, CAROLINE S.; NOBREGA, MARCELO M.; TEMPERINI, MARCIA L. A.; CONSTANTINO, VERA R. L.. Hybrid Ni-Al layered double hydroxide: Characterization and in situ synchrotron XRD and vibrational spectroscopic studies under high-pressure. APPLIED CLAY SCIENCE, v. 174, p. 152-158, . (16/21070-5, 11/50318-1, 15/09763-2, 14/04816-8, 14/15107-8)
PEROTTI, GUSTAVO F.; BORTOTTI, JESSICA R.; LIMA, FILIPE S.; MICHELS, LEANDER; DOS SANTOS, EVERTON C.; ALTOE, MARIO A. S.; GRASSI, GIOVANNI; SILVA, GERALDO J.; DROPPA-JR, ROOSEVELT; FOSSUM, JON O.; et al. Exfoliation of carboxymethylcellulose-intercalated layered double hydroxide in water. APPLIED CLAY SCIENCE, v. 205, p. 8-pg., . (11/50318-1)
ALVARADO HUAYHUAZ, JESUS ANTONIO; VITORINO, HECTOR AGUILAR; CAMPOS, OTHON SOUTO; PIRES SERRANO, SILVIA HELENA; KANEKO, TELMA MARY; ESPOSITO, BRENO PANNIA. Desferrioxamine and desferrioxamine-caffeine as carriers of aluminum and gallium to microbes via the Trojan Horse Effect. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 41, p. 16-22, . (16/03709-9, 11/50318-1)
CAVICCHIOL, MAURICIO; LINO ZABALLA, ALINE MONTEIRO; DE PAULA, QUEITE ANTONIA; PRIETO, MARCELA BACH; OLIVEIRA, CARLA COLUMBANO; CIVITAREALE, PATRIZIA; CIRIOLO, MARIA ROSA; DA COSTA FERREIRA, ANA MARIA. Oxidative Assets Toward Biomolecules and Cytotoxicity of New Oxindolimine-Copper(II) and Zinc(II) Complexes. INORGANICS, v. 7, n. 2, . (11/50318-1, 13/07937-8)
PORTES, MARCELO CECCONI; DE MORAES, JOSUE; COSTA VERAS, LEIZ MARIA; LEITE, JOSE ROBERTO; MAFUD, ANA CAROLINA; MASCARENHAS, YVONNE PRIMERANO; VIRGINO LUZ, ADAMOR ELEIEL; DALMATTI ALVES DE LIMA, FILIPE CAMARGO; DO NASCIMENTO, RAFAEL RODRIGUES; PETRILLI, HELENA MARIA; et al. Structural and spectroscopic characterization of epiisopiloturine-metal complexes, and anthelmintic activity vs. S-mansoni. Journal of Coordination Chemistry, v. 69, n. 10, p. 1663-1683, . (11/50318-1, 14/02282-6, 12/02326-8, 13/07937-8)
SILVA, CLAUDIO H. B.; ILIUT, MARIA; MURYN, CHRISTOPHER; BERGER, CHRISTIAN; COLDRICK, ZACHARY; CONSTANTINO, VERA R. L.; TEMPERINI, MARCIA L. A.; VIJAYARAGHAVAN, ARAVIND. Ternary nanocomposites of reduced graphene oxide, polyaniline and hexaniobate: hierarchical architecture and high polaron formation. BEILSTEIN JOURNAL OF NANOTECHNOLOGY, v. 9, p. 2936-2945, . (11/50318-1, 13/03013-6, 12/13119-3, 14/05048-4)
ARANDA, ESTHER ESCRIBANO; DA LUZ, JULIANA SILVA; OLIVEIRA, CARLA COLUMBANO; DIVINA PETERSEN, PHILIPPE A.; PETRILLI, HELENA M.; DA COSTA FERREIRA, ANA M.. Heterobinuclear copper(II)-platinum(II) complexes with oxindolimine ligands: Interactions with DNA, and inhibition of kinase and alkaline phosphatase proteins. Journal of Inorganic Biochemistry, v. 203, . (11/50318-1, 13/07937-8, 12/17671-2)
DE MATOS, CAROLINE SILVA; GHIMBEU, CAMELIA MATEI; BRENDLE, JOCELYNE; LIMOUSY, LIONEL; CONSTANTINO, VERA REGINA LEOPOLDO. Thermal decomposition of a layered double hydroxide as a bottom up approach for the synthesis of metallic nanoparticles embedded in carbon structures. NEW JOURNAL OF CHEMISTRY, v. 44, n. 39, p. 16721-16732, . (18/15201-5, 14/04816-8, 11/50318-1)
PEROTTI, GUSTAVO F.; KIJCHAVENGKUL, THITISILP; AURAS, RAFAEL A.; CONSTANTINO, VERAR. L.. Nanocomposites Based on Cassava Starch and Chitosan-Modified Clay: Physico-Mechanical Properties and Biodegradability in Simulated Compost Soil. Journal of the Brazilian Chemical Society, v. 28, n. 4, p. 649-658, . (11/50318-1)
BEMARDINO, N. D.; CONSTANTINO, V. R. L.; DE FARIA, D. L. A.. Probing the Indigo Molecule in Maya Blue Simulants with Resonance Raman Spectroscopy. Journal of Physical Chemistry C, v. 122, n. 21, p. 11505-11515, . (11/50318-1, 12/05643-4, 12/13119-3)
DE MORAES, JOSUE; DARIO, BRUNO S.; COUTO, RICARDO A. A.; PINTO, PEDRO L. S.; DA COSTA FERREIRA, ANA M.. Antischistosomal Activity of Oxindolimine-Metal Complexes. Antimicrobial Agents and Chemotherapy, v. 59, n. 10, p. 6648-6652, . (11/50318-1)
BERNARDINO, NATHALIA D.; CONSTANTINO, VERA R. L.; DE FARIA, DALVA L. A.. Probing the chemical reactivity of interfaces: Investigation on the interaction of dehydroindigo with Laponite by UV-vis, Raman and infrared spectroscopy. VIBRATIONAL SPECTROSCOPY, v. 94, p. 83-88, . (12/13119-3, 11/50318-1, 12/05643-4)
KANG, HA RAM; DA COSTA FERNANDES, CELIO JUNIOR; DA SILVA, RODRIGO AUGUSTO; LEOPOLDO CONSTANTINO, VERA REGINA; JUN KOH, IVAN HONG; ZAMBUZZI, WILLIAN F.. Mg-Al and Zn-Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen-Activated Protein Kinases. ADVANCED HEALTHCARE MATERIALS, v. 7, n. 4, . (11/50318-1, 14/22689-3)
OLIVEIRA, ROSELAINE DA S.; CAMILO, FERNANDA F.; BIZETO, MARCOS A.. Evaluation of the influence of sulfur-based functional groups on the embedding of silver nanoparticles into the pores of MCM-41. Journal of Solid State Chemistry, v. 235, p. 125-131, . (11/50318-1)
VITORINO, HECTOR AGUILAR; MANTOVANELLI, LUCA; ZANOTTO, FLAVIA PINHEIRO; ESPOSITO, BRENO PANNIA. Iron Metallodrugs: Stability, Redox Activity and Toxicity against Artemia salina. PLoS One, v. 10, n. 4, . (11/50318-1)
ROCHA, MICHELE A.; PETERSEN, PHILIPPE A. D.; TEIXEIRA-NETO, ERICO; PETRILLI, HELENA M.; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE; CONSTANTINO, VERA R. L.. Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release. RSC ADVANCES, v. 6, n. 20, p. 16419-16436, . (11/50318-1)
NUNES, CLEIA JUSTIN; BORGES, BEATRIZ ESSENFELDER; NAKAO, LIA SUMIE; PEYROUX, EUGENIE; HARDRE, RENAUD; FAURE, BRUNO; REGLIER, MARIUS; GIORGI, MICHEL; PRIETO, MARCELA BACH; OLIVEIRA, CARLA COLUMBANO; et al. Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity. Journal of Inorganic Biochemistry, v. 149, p. 49-58, . (11/50318-1, 13/07937-8, 14/09367-7)
PEROTTI, GUSTAVO F.; BARUD, HERNANE S.; RIBEIRO, SIDNEY J. L.; CONSTANTINO, VERA R. L.. Bacterial cellulose as a template for preparation of hydrotalcite-like compounds. Journal of the Brazilian Chemical Society, v. 25, n. 9, p. 1647-1655, . (11/50318-1)
MACEDO, RAFAEL DOS SANTOS; ULSEN, CARINA; MUELLER, ANETTE. Quantification of residual cement paste on recycled concrete aggregates containing limestone by selective dissolution. CONSTRUCTION AND BUILDING MATERIALS, v. 229, . (11/50318-1)
LIMA, C. R. R. C.; LIMA, R. J. S.; BANDEIRA, A. C. C.; COUTO, R. A. A.; VELASCO, M. V. R.; BORDALLO, H. N.; OLIVEIRA, C. L. P.. Alterations promoted by acid straightening and/or bleaching in hair microstructures. JOURNAL OF APPLIED CRYSTALLOGRAPHY, v. 56, p. 13-pg., . (11/50318-1, 16/24531-3)
FAZZI, RODRIGO B.; FERRAZ DE PAIVA, RAPHAEL E.; DA COSTA FERREIRA, ANA M.. A combined EPR spectroscopy and DFT-based structural interpretation of the antitumor properties of oxindolimine-copper(II) complexes. ARKIVOC, v. N/A, p. 11-pg., . (11/50318-1, 18/21537-6, 13/07937-8)
DE PAULA, QUEITE A.; JOLY, JEAN-PIERRE; SELMECZI, KATALIN; FONSECA, DAVID E. P.; CARAMORI, GIOVANNI F.; FARRELL, NICHOLAS P.; DA COSTA FERREIRA, ANA M.. Binding affinity studies of 1,2,3-triazole copper(II) complexes to human serum albumin. Journal of Coordination Chemistry, v. 71, n. 11-13, p. 16-pg., . (13/07937-8, 11/50318-1)
COUTO, RICARDO ALEXANDRE ALVES; MIGUEL, RODRIGO BERNARDI; VIEIRA, EDUARDO GUIMARAES; BRENDLE, JOCELYNE; LIMOUSY, LIONEL; CONSTANTINO, VERA REGINA LEOPOLDO; FERREIRA, ANA MARIA DA COSTA. Synthetic beidellite clay as nanocarrier for delivery of antitumor oxindolimine-metal complexes. Journal of Inorganic Biochemistry, v. 240, p. 12-pg., . (11/50318-1, 16/50317-9, 16/16735-8)
DARIO, BRUNO SOARES; NETO, FRANCISCO FERNANDES; PORTES, MARCELO CECCONI; FAZZI, RODRIGO BONI; DA SILVA, DANIEL RODRIGUES; PETERSON, ERICA J.; FARRELL, NICHOLAS PATRICK; CASTELLI, SILVIA; DESIDERI, ALESSANDRO; DIVINA PETERSEN, PHILIPPE ALEXANDRE; et al. DNA binding, cytotoxic effects and probable targets of an oxindolimine-vanadyl complex as an antitumor agent. NEW JOURNAL OF CHEMISTRY, v. 43, n. 45, p. 17831-17840, . (11/50318-1, 13/07937-8)
DE PAULA, QUEITE A.; JOLY, JEAN-PIERRE; SELMECZI, KATALIN; FONSECA, DAVID E. P.; CARAMORI, GIOVANNI F.; FARRELL, NICHOLAS P.; DA COSTA FERREIRA, ANA M.. Binding affinity studies of 1,2,3-triazole copper(II) complexes to human serum albumin. Journal of Coordination Chemistry, v. 71, n. 11-13, SI, p. 1894-1909, . (11/50318-1, 13/07937-8)
SCHLEH, FREDERICO A.; CHIARELLI-NETO, ORLANDO; FONTES, MAYARA N.; NAJJAR, RENATO; ESPOSITO, BRENO P.. Phytate decreases oxidative damage caused by labile forms of iron in solution, blood plasma and in HeLa cells. Journal of the Brazilian Chemical Society, v. 25, n. 6, p. 1036-1040, . (11/50318-1, 12/04875-9)
GUSTAVO F. PEROTTI; JAIRO TRONTO; MARCOS A. BIZETO; CELLY M. S. IZUMI; MARCIA L. A. TEMPERINI; ADEMAR B. LUGÃO; DUCLERC F. PARRA; VERA R. L. CONSTANTINO. Biopolymer-clay nanocomposites: cassava starch and synthetic clay cast films. Journal of the Brazilian Chemical Society, v. 25, n. 2, p. 320-330, . (11/50318-1)
PEREIRA, TATIANA ARAUJO; TEIXEIRA DA SILVA, GISELE ESPINHA; HERNANDEZ, RAUL BONNE; FORTI, FABIO LUIS; ESPOSITO, BRENO PANNIA. Antitumor activity of Mn(III) complexes in combination with phototherapy and antioxidant therapy. BIOMETALS, v. 26, n. 3, p. 439-446, . (11/50318-1)
FIGUEIRECLO, MARIANA P.; CUNH, VANESSA R. R.; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE; NAKAMAE, MARTA N.; KANG, YE R.; SOUZA, RODRIGO B.; MARTINS, ANA MARIA C. R. P. F.; JUN KOH, IVAN HONG; CONSTANTINO, VERA R. L.. Iron-Based Layered Double Hydroxide Implants: Potential Drug Delivery Carriers with Tissue Biointegration Promotion and Blood Microcirculation Preservation. ACS OMEGA, v. 3, n. 12, p. 18263-18274, . (14/15900-0, 11/50318-1, 16/13862-9, 16/50317-9)
FELTRAN, GEORGIA DA SILVA; DA COSTA FERNANDES, CELIO JUNIOR; FERREIRA, MARCEL RODRIGUES; KANG, HA RAM; DE CARVALHO BOVOLATO, ANA LIVIA; GOLIM, MARJORIE DE ASSIS; DEFFUNE, ELENICE; JUN KOH, IVAN HONG; LEOPOLDO CONSTANTINO, VERA REGINA; ZAMBUZZI, WILLIAN F.. Sonic hedgehog drives layered double hydroxides-induced acute inflammatory landscape. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 174, p. 467-475, . (11/50318-1, 14/22689-3)
EUFRASIO PINTO, MARINA DE CARVALHO; LIMA GONCALVES, ROSEMBERGUE GABRIEL; MENEZES DOS SANTOS, RODRIGO MORAIS; ARAUJO, EMILIANE ANDRADE; PEROTTI, GUSTAVO FRIGI; MACEDO, RAFAEL DOS SANTOS; BIZETO, MARCOS AUGUSTO; LEOPOLDO CONSTANTINO, VERA REGINA; PINTO, FREDERICO GARCIA; TRONTO, JAIRO. Mesoporous carbon derived from a biopolymer and a clay: Preparation, characterization and application for an organochlorine pesticide adsorption. Microporous and Mesoporous Materials, v. 225, p. 342-354, . (11/50318-1)
ALTA, ROXANA Y. P.; VITORINO, HECTOR A.; GOSWAMI, DIBAKAR; LIRIA, CLEBER W.; WISNOVSKY, SIMON P.; KELLEY, SHANA O.; MACHINI, M. TERESA; ESPOSITO, BRENO P.. Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron. PLoS One, v. 12, n. 2, . (16/03709-9, 11/50318-1, 12/09068-4)
CASTELLI, SILVIA; GONCALVES, MARCOS BROWN; KATKAR, PRAFULLA; STUCHI, GABRIELA CRISTINA; ALVES COUTO, RICARDO ALEXANDRE; PETRILLI, HELENA MARIA; DA COSTA FERREIRA, ANA MARIA. Comparative studies of oxindolimine-metal complexes as inhibitors of human DNA topoisomerase IB. Journal of Inorganic Biochemistry, v. 186, p. 85-94, . (11/50318-1, 12/03080-2, 13/07937-8)
RIBEIRO DE CASTRO LIMA, CIBELE ROSANA; ALVES DE COUTO, RICARDO ALEXANDRE; FREIRE, THAMIRES BATELLO; GOSHIYAMA, ALESSANDRA MARI; BABY, ANDRE ROLIM; ROBLES VELASCO, MARIA VALERIA; LEOPOLDO CONSTANTINO, VERA REGINA; MATOS, JIVALDO DO ROSARIO. Heat-damaged evaluation of virgin hair. Journal of Cosmetic Dermatology, v. 18, n. 6, p. 1885-1892, . (11/50318-1)
RODRIGUES CUNHA, VANESSA ROBERTA; DE SOUZA, RODRIGO BARBOSA; PINTO DA FONSECA MARTINS, ANA MARIA CRISTINA REBELLO; JUN KOH, IVAN HONG; LEOPOLDO CONSTANTINO, VERA REGINA. Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation. SCIENTIFIC REPORTS, v. 6, . (11/50318-1, 12/12209-9)
WEGERMANN, CAMILA ANCHAU; PIROTA, VALENTINA; MONZANI, ENRICO; CASELLA, LUIGI; COSTA, LUIZ ANTONIO SODRE; NOVATO, WILLIAN TASSIO GOMES; MACHINI, M. TERESA; FERREIRA, ANA MARIA DA COSTA. Interaction studies of oxindole-derivatives with beta-amyloid peptides inhibiting its aggregation induced by metal ions. Journal of Inorganic Biochemistry, v. 245, p. 16-pg., . (11/50318-1, 15/14360-4, 13/07937-8)
MAGRI, VAGNER R.; DUARTE, ALFREDO; PEROTTI, GUSTAVO F.; CONSTANTINO, VERA R. L.. Investigation of Thermal Behavior of Layered Double Hydroxides Intercalated with Carboxymethylcellulose Aiming Bio-Carbon Based Nanocomposites. CHEMENGINEERING, v. 3, n. 2, p. 17-pg., . (11/50318-1)

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Filed patent(s) as a result of this research project

COMPLEXOS METÁLICOS COM LIGANTES INDÓLICOS OU OXINDÓLICOS E SEUS DERIVADOS IMiNICOS E SEU USO COMO AGENTES ANTIPARASITÁRIOS BR1020130265586 - Universidade de São Paulo (USP) ; Universidade Federal de Minas Gerais (UFMG) . Ana Maria da C. Ferreira ; Gustavo Levendoski Sabino ; Queite Antonia de Paula ; Ricardo Alexandre de Couto ; Bruno Soares Dario ; Leda Quercia Vieira ; Grazielle Alves Ribeiro - October 2013, 15