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Evaluation of mechanical-chemical gingival therapy of diabetic, obese or obese diabetic subjects: quantitative and qualitative analysis of local and systemic aspects.

Grant number: 10/20424-1
Support Opportunities:Regular Research Grants
Duration: September 01, 2011 - August 31, 2013
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Sheila Cavalca Cortelli
Grantee:Sheila Cavalca Cortelli
Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade de Taubaté (UNITAU). Taubaté , SP, Brazil
Associated researchers: Davi Romeiro Aquino ; Fernando de Oliveira Costa ; Gilson Cesar Nobre Franco ; José Roberto Cortelli ; Karina Cogo Müller ; Priscila Romeiro Aquino


The present study hypothesized that some systemic conditions such as, diabetes and obesity, could affect negatively the response to gingival treatment. Aims: this interventional study will evaluate if diabetes, obesity or its association interfere in the host response to mechanical-chemical treatment of gingivitis. Also, to evaluate the relation between oral health and either quality of life or daily performance of systemically compromised subjects. Methods: 240 gingivitis subjects will be selected and divided in 4 groups: diabetes (n=60), obesity (n=60), diabetes+obesity (n=60) and control (systemically healthy, n=60), in addition to a negative control group (systemic and gingival health, n=60). All groups will receive professional prophylaxis (ultrasonic and/or rubber cup and prophylaxis paste, according to their gingival status) and oral hygiene instructions. Subsequently, subjects from each group will be randomly allocated in test (Listerine total care; n=30) or placebo (n=30). The parameters that will be measured at baseline and 90 days are: clinical - plaque índex, gingival índex and probing depth; microbiological: quantification (qPCR) of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tanerella forsythia, Treponema denticola, and Streptococcus oralis in gingival samples; imune: volume and composition of gingival crevicular fluid (ELISA detection of cytokines); salivary: flow and composition (total protein level); halitosis: organoleptic analysis and halitometry; questionnaires focusing on relation between oral status and quality of life (OHQOL - Oral Health and Quality of Life questionnaire) and daily performances (OIDP - Oral Impacts on Daily Performances questionnaire). Intra-group (baseline vs. 90 days) and inter-groups (at each experimental time) comparisons will be performed using the software Bio Estat 5.0 and SPSS 14.0. Expected results: to determine the efficacy of the mechanical-chemical therapy in subjects diagnosed with diabetes, obesity or diabetes + obesity. Also, to determine if these systemic conditions influence the response to periodontal treatment. Finally, it could be analyzed if these systemic conditions as well as the proposed therapy influence the self-detected quality of life and volunteers' daily performance. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PATARO, ANDRE LUIZ; CORTELLI, SHEILA CAVALCA; NOGUEIRA GUIMARAES ABREU, MAURO HENRIQUE; CORTELLI, JOSE ROBERTO; NOBRE FRANCO, GILSON CESAR; AQUINO, DAVI ROMEIRO; COTA, LUIS OTAVIO MIRANDA; COSTA, FERNANDO OLIVEIRA. Frequency of periodontal pathogens and Helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study. Journal of Applied Oral Science, v. 24, n. 3, p. 229-238, . (10/20424-1)
RASLAN, SUZANE A.; CORTELLI, JOSE R.; COSTA, FERNANDO O.; AQUINO, DAVI R.; FRANCO, GILSON C. N.; COTA, LUIS O. M.; GARGIONI-FILHO, ANTONIO; CORTELLI, SHEILA C.. Clinical, Microbial, and Immune Responses Observed in Patients With Diabetes After Treatment for Gingivitis: A Three-Month Randomized Clinical Trial. Journal of Periodontology, v. 86, n. 4, p. 516-526, . (10/20424-1, 11/02371-0)
CORTELLI, SHEILA C.; COSTA, FERNANDO O.; GARGIONI-FILHO, ANTONIO; AQUINO, DAVI R.; COTA, LUIS O. M.; SCHERMA, ALEXANDRE P.; MIRANDA, THIS B.; CORTELLI, JOSE R.. Impact of gingivitis treatment for diabetic patients on quality of life related to periodontal objective parameters: A randomized controlled clinical trial. ARCHIVES OF ORAL BIOLOGY, v. 86, p. 80-86, . (15/02995-5, 10/20424-1)

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