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Do green-tea and Tempol (superoxide mimitic) present an beneficial effect in the pathogenesis of diabetic retinopathy? An in vivo study using human retinal pigmented epithelium cells (ARPE-19)

Grant number: 11/06719-1
Support Opportunities:Regular Research Grants
Duration: September 01, 2011 - August 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Jacqueline Mendonça Lopes de Faria
Grantee:Jacqueline Mendonça Lopes de Faria
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Diabetic retinopathy (DR) is the leading cause of blindness in United States. DR is a neurodegenerative disease accompanied by extensive vascular changes. An early marker of DR is blood retinal barrier (BRB) breakdown, both inner and outer BRB. The inner retinal barrier is formed by endothelial/pericytes and the outer retinal barrier by the pigmented epithelial retinal cell. ARPE-19 is a transformed cell and is an appropriate system to evaluated the outer retinal barrier. Findings from our group demonstrated the beneficial effects of antioxidants (tempol and green tea) in retina from experimental diabetic rats. The aim of the present work is to evaluate in vitro the possible mechanisms involved in the effects of antioxidants compounds in the treatment of DR. The specific objectives are to evaluate the transepithelial permeability and the anti and pro-oxidants systems present in ARPE-19 in presence of high glucose with or without treatment (tempol and green tea). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSALES, MARIANA APARECIDA B.; SILVA, KAMILA CRISTINA; DUARTE, DIEGO A.; ROSSATO, FRANCO APARECIDO; DE FARIA, JOSE B. LOPES; LOPES DE FARIA, JACQUELINE M.. Endocytosis of Tight Junctions Caveolin Nitrosylation Dependent Is Improved by Cocoa Via Opioid Receptor on RPE Cells in Diabetic Conditions. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 55, n. 9, p. 6090-6100, . (11/06719-1, 08/57560-0)
ROSALES, MARIANA A. B.; SILVA, KAMILA C.; DUARTE, DIEGO A.; DE OLIVEIRA, MARCELO G.; DE SOUZA, GABRIELA F. P.; CATHARINO, RODRIGO R.; FERREIRA, MONICA S.; LOPES DE FARIA, JOSE B.; LOPES DE FARIA, JACQUELINE M.. S-Nitrosoglutathione Inhibits Inducible Nitric Oxide Synthase Upregulation by Redox Posttranslational Modification in Experimental Diabetic Retinopathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 55, n. 5, p. 2921-2932, . (11/06719-1, 08/57560-0)

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