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Mechanisms related to increased cardiovascular risk in spinal cord injury subjects

Grant number: 10/16252-0
Support Opportunities:Regular Research Grants
Duration: September 01, 2011 - September 30, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Wilson Nadruz Junior
Grantee:Wilson Nadruz Junior
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Alberto Cliquet Junior


Clinical and epidemiological data have demonstrated that spinal cord injury (SCI) subjects exhibit higher prevalence of cardiovascular diseases in comparison with the general population. Likewise, our group recently showed that subjects with chronic SCI presented higher carotid intima-media thickness (IMT) and worse left ventricular diastolic function than able-bodied ones. These findings were independent of traditional risk factors, such as age, hypertension, body mass index, metabolic alterations, smoking and plasmatic levels of inflammatory markers. Conversely, new data from our institution demonstrate that carotid IMT from normotensive SCI individuals exhibits a strong correlation with diastolic blood pressure measured on Ambulatory Blood Pressure Monitoring, suggesting that cells from such subjects are more sensitive to hemodynamic/mechanical stimuli, even within normal blood pressure ranges. This body of evidence indicates that the study of human SCI might expand the comprehension of atherosclerosis and left ventricular diastolic dysfunction physiopathology. The aim of this study is to investigate potential mechanisms underlying the higher cardiovascular risk detected in SCI subjects. In this regard, we will evaluate the role of renin-angiotensin-aldosterone axis, sympathetic system, metalloproteinases and hemodynamic/mechanical stimuli in the development of SCI-related atherosclerosis and left ventricular diastolic dysfunction. (AU)

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Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SCHREIBER, R.; FERREIRA-SAE, M. C.; TUCUNDUVA, A. C.; MILL, J. G.; COSTA, FELIPE O.; KRIEGER, J. E.; FRANCHINI, K. G.; PEREIRA, A. C.; NADRUZ, JR., W.. CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients. DIABETIC MEDICINE, v. 29, n. 7, p. E55-E61, . (10/16252-0)
SCHREIBER, ROBERTO; FERREIRA-SAE, MARIA C.; RONCHI, JULIANA A.; PIO-MAGALHAES, JOSE A.; CIPOLLI, JOSE A.; MATOS-SOUZA, JOSE R.; MILL, JOSE G.; VERCESI, ANIBAL E.; KRIEGER, JOSE E.; FRANCHINI, KLEBER G.; et al. The C242T polymorphism of the p22-phox gene (CYBA) is associated with higher left ventricular mass in Brazilian hypertensive patients. BMC MEDICAL GENETICS, v. 12, . (10/16252-0)
GEMIGNANI, TIAGO; AZEVEDO, RENATA C.; HIGA, CELINA M.; COELHO, OTAVIO R.; MATOS-SOUZA, JOSE R.; NADRUZ, JR., WILSON. Increased popliteal circumferential wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques. ATHEROSCLEROSIS, v. 224, n. 1, p. 118-122, . (10/16252-0)
PAIM, LAYDE R.; SCHREIBER, ROBERTO; MATOS-SOUZA, JOSE R.; SILVA, ANSELMO A.; CAMPOS, LUIS F.; AZEVEDO, ELIZA R.; ALONSO, KARINA; DE ROSSI, GUILHERME; ETCHEBEHERE, MAURICIO; GORLA, JOSE I.; et al. Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects. ATHEROSCLEROSIS, v. 231, n. 2, p. 341-345, . (10/16252-0)
MENDES, PAULO R.; KIYOTA, TATIANA A.; CIPOLLI, JOSE A.; SCHREIBER, ROBERTO; PAIM, LAYDE R.; BELLINAZZI, VERA R.; MATOS-SOUZA, JOSE R.; SPOSITO, ANDREI C.; NADRUZ, JR., WILSON. Gender influences the relationship between lung function and cardiac remodeling in hypertensive subjects. HYPERTENSION RESEARCH, v. 38, n. 4, p. 264-268, . (10/16252-0)
SCHREIBER, ROBERTO; PAIM, LAYDE R.; DE ROSSI, GUILHERME; MATOS-SOUZA, JOSE R.; COSTA E SILVA, ANSELMO DE A.; SOUZA, CRISTIANE M.; BORGES, MARIANE; AZEVEDO, ELIZA R.; ALONSO, KARINA C.; GORLA, JOSE I.; et al. Matrix metalloproteinases and left ventricular function and structure in spinal cord injured subjects. Clinica Chimica Acta, v. 437, p. 136-140, . (10/16252-0)
ADDEO CIPOLLI, JOSE ALEXANDRE; FERREIRA-SAE, MARIA CAROLINA; MARTINS, RAFAEL PRADO; PIO-MAGALHAES, JOSE ALEXANDRE; BELLINAZZI, VERA REGINA; MATOS-SOUZA, JOSE ROBERTO; NADRUZ JUNIOR, WILSON. Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study. BMC CARDIOVASCULAR DISORDERS, v. 12, . (10/16252-0)
PEREIRA, EDUARDO B.; GEMIGNANI, TIAGO; SPOSITO, ANDREI C.; MATOS-SOUZA, JOSE R.; NADRUZ, JR., WILSON. Low-density lipoprotein cholesterol and radiotherapy-induced carotid atherosclerosis in subjects with head and neck cancer. RADIATION ONCOLOGY, v. 9, . (10/16252-0)
SCHREIBER, ROBERTO; BELLINAZZI, VERA REGINA; SPOSITO, ANDREI C.; MILL, JOSE G.; KRIEGER, JOSE E.; PEREIRA, ALEXANDRE C.; NADRUZ, JR., WILSON. Influence of the C242T Polymorphism of the p22-phox Gene (CYBA) on the Interaction between Urinary Sodium Excretion and Blood Pressure in an Urban Brazilian Population. PLoS One, v. 8, n. 12, . (10/16252-0)
GEMIGNANI, TIAGO; MATOS-SOUZA, JOSE R.; FRANCHINI, KLEBER G.; NADRUZ, JR., WILSON. Leg Blood Pressure Measured in Orthostatic Posture Is Associated With Left Ventricular Mass in Normotensive Subjects. AMERICAN JOURNAL OF HYPERTENSION, v. 25, n. 10, p. 1083-1087, . (10/16252-0)
KIYOTA, TATIANA A.; MENDES, PAULO R.; CIPOLLI, JOSE A.; SCHREIBER, ROBERTO; PAIM, LAYDE R.; BELLINAZZI, VERA R.; MATOS-SOUZA, JOSE R.; SPOSITO, ANDREI C.; NADRUZ, JR., WILSON. Lung age is related to carotid structural alterations in hypertensive subjects. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, v. 8, n. 6, p. 381-387, . (10/16252-0)
MESQUITA, ROBERTO F.; REIS, MURIEL; BEPPLER, ANA PAULA; BELLINAZZI, VERA REGINA; MATTOS, SANDRA S.; LIMA-FILHO, JOSE L.; CIPOLLI, JOSE A.; COELHO-FILHO, OTAVIO R.; PIO-MAGALHAES, JOSE A.; SPOSITO, ANDREI C.; et al. Onset of hypertension during pregnancy is associated with long-term worse blood pressure control and adverse cardiac remodeling. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, v. 8, n. 11, p. 827-831, . (10/16252-0)

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