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Production and application of proteases from Aspergillus oryzae to obtain peptides with biological activity

Abstract

Protease producing by micro-organisms has been used for centuries in Japan, Korea and China for the production of fermented foods, involving the hydrolysis of soy protein, wheat and other cereals. The fungus Aspergillus oryzae is a major producer of enzymes such as protease, amylase and ²-glucosidases and is considered safe for use in foods. The use of biotechnological processes such as solid-state fermentation for the production of proteases has aroused great economic interest due to the possibility of using agroindustrial residues as the culture medium, these being cheap raw materials, widely distributed in Brazil. Amongst the new applications of proteases the production of bioactive molecules stands out. It has been demonstrated that many peptides derived from food protein hydrolysates show antioxidant, antimicrobial and anti-adipogenic activities. In this context, the present paper aims to study the production and biochemical characterization of the protease produced by A. oryzae in semi-solid fermentation and to evaluate the application of this enzyme and of commercial protease preparations in obtaining protein hydrolysates studying the antioxidant, antimicrobial and anti-adipogenic activities of any bioactive peptides present. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOARES DE CASTRO, RUANN JANSER; SATO, HELIA HARUMI. A response surface approach on optimization of hydrolysis parameters for the production of egg white protein hydrolysates with antioxidant activities. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 4, n. 1, p. 55-62, . (11/10429-9)
DE CASTRO, RUANN JANSER SOARES; SATO, HELIA HARUMI. Production and biochemical characterization of protease from Aspergillus oryzae: An evaluation of the physical-chemical parameters using agroindustrial wastes as supports. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 3, n. 3, p. 6-pg., . (11/10429-9)
DE CASTRO, RUANN JANSER SOARES; SATO, HELIA HARUMI. Advantages of an acid protease from Aspergillus oryzae over commercial preparations for production of whey protein hydrolysates with antioxidant activities. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 3, n. 3, p. 8-pg., . (11/10429-9)
SOARES DE CASTRO, RUANN JANSER; NISHIDE, TANIA GOIA; SATO, HELIA HARUMI. Production and biochemical properties of proteases secreted by Aspergillus niger under solid state fermentation in response to different agroindustrial substrates. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 3, n. 4, p. 10-pg., . (11/10429-9)
SOARES DE CASTRO, RUANN JANSER; INACIO, RODRIGO FABRIZZIO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE; SATO, HELIA HARUMI. Statistical optimization of protein hydrolysis using mixture design: Development of efficient systems for suppression of lipid accumulation in 3T3-L1 adipocytes. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 5, p. 17-23, . (11/10429-9)
DE CASTRO, RUANN J. S.; SATO, HELIA H.. Antioxidant activities and functional properties of soy protein isolate hydrolysates obtained using microbial proteases. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, v. 49, n. 2, p. 317-328, . (11/10429-9)

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