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S-nitrosation of proteins involved in insulin and leptin signaling pathways in the hypothalamus of obese rodents: a novel mechanism involved in obesity genesis

Grant number: 10/19503-4
Support Opportunities:Regular Research Grants
Duration: July 01, 2011 - June 30, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:José Barreto Campello Carvalheira
Grantee:José Barreto Campello Carvalheira
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The hypothalamus is a brain region that gathers information on the body's nutritional status and governs the release of multiple metabolic signaling molecules such as insulin and leptin to maintain homeostasis. Obesity is associated with insulin and leptin resistance in the hypothalamus. However, despite it was recently demonstrated that the insulin resistance is associated with the increase in inducible nitric oxide synthase (iNOS) is, at least in part, mediated by S-nitrosation of proteins involved in insulin signal transduction: insulin receptor b-subunit (IRb), insulin receptor substrate 1(IRS-1), and Akt. The role of S-nitrosation of insulin and leptin signaling in hypothalamus is not clear. Thus the major aim of this study is to characterize the S-nitrosation of the proteins IR, IRS-1, Akt e da STAT3 in hypothalamus of obese rodents and investigate the relationship of this phenomenon with leptin and insulin resistance as well as with the control of food intake. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KATASHIMA, CARLOS KIYOSHI; RODRIGUES SILVA, VAGNER RAMON; LENHARE, LUCIENE; MARIN, RODRIGO MIGUEL; CAMPELLO CARVALHEIRA, JOSE BARRETO. iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents. SCIENTIFIC REPORTS, v. 7, . (10/19503-4)
DA CUNHA, LORENA PIRES; SILVEIRA, MARINA NOGUEIRA; SANTOS MENDES, MARIA CAROLINA; COSTA, FELIPE OSORIO; MACEDO, LIGIA TRALDI; DE SIQUEIRA, NADIA SCLEARUC; CAMPELLO CARVALHEIRA, JOSE BARRETO. Sarcopenia as an independent prognostic factor in patients with metastatic colorectal cancer: A retrospective evaluation. CLINICAL NUTRITION ESPEN, v. 32, p. 107-112, . (10/19503-4, 13/07607-8)

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