Biomaterials based on phosphates of calcium collagen for reconstitution of bone tissue

Abstract

The aim of this project is to develop ceramicand collagen-derived materials in the form of membrane for use in mouth-jaw-face reconstruction. Its indication is associated with bone defects caused by the very pathology itself and/or by surgical treatment which results in defects such as bone cavities, mucous bone dehiscence, and gingival retraction associated with chronic inflammatory processes of the jaws, such as cysts, granulomas and other tumors. The proposed materials may also benefit patients with indication of tooth extraction and indication of immediate dental implant with concomitant need for graft. The ceramics proposed in this project are derived from salts of calcium phosphate and correspond to: 1) non-stequiometric hydroxyapatite (HA) for application in bone tissue reconstruction of small volume defects, and which in the form of green cake (raw preparation of HA) will be obtained by synthetic process, to replace similar materials which contain B-TCP and HA, the cost of which is higher in relation to processing; 2) biphasic ceramics (BCP) made of non-stequiometric B-TCP:HA which, on account of significant differences in solubility, allow for the formulation of ceramic preparations more suited to the volume of the reconstruction of tissue simply because of the variation in the proportion of the two hemihydrated ceramics; and 3) injectable ceramics intended for mouth-jaw-face reconstruction to minimize ceramic migration. (AU)