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Evaluation of the peripheral effect of 15d-PGJ2 on rheumatoid arthritis-induced inflammatory response in the TMJ of rats


Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that results in the destruction of cartilage and bone including the temporomandibular joint (TMJ). The inflammatory process started in the synovial membrane and due to its progressive characteristics extends to the articular superficies leading to deformation and articular destruction of the bone and cartilages. The TMJ afflicted with RA may produce pain, joint stiffness, difficulties in opening the mouth, and open bite. Spite the severity of the temporomandibular dysfunction (TMD) promoted by RA induce important injury, the TMD are frequently ignored by the rheumatologists or by the patients, since the treatments are focused on the other articulations as well as due to the limitations of the diagnostic techniques. The literature has demonstrated that the prevalence of RA range almost 1% of the adults, in which women are 3 to 4 times more affected than men. Besides, it has been demonstrated that the activation of the PPAR-g receptors by 15d-PGJ2, suppress the arthritis induced by adjuvant in rats, decreasing the pannus formation and the inflammatory infiltrate. Considering previous studies in which the peripheral administration of 15d-PGJ2 showed a potent antinociceptive and anti-inflammatory effect in the TMJ though the activation of PPAR-g and opioid receptors, the present study has the objective to evaluate the effect of the 15d-PGJ2 in the TMD triggered by RA. Considering the difficult of a correct diagnostic as well as of the elaboration of validate therapeutic for the temporomandibular disorders, the development of the present study will contribute with the basic knowledge for the determination of a potential therapeutic treatment specifically for the painful conditions from the TMJ. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
QUINTEIRO, M. S.; NAPIMOGA, M. H.; MESQUITA, K. P.; CLEMENTE-NAPIMOGA, J. T.. The indirect antinociceptive mechanism of 15d-PGJ(2) on rheumatoid arthritis-induced TMJ inflammatory pain in rats. EUROPEAN JOURNAL OF PAIN, v. 16, n. 8, p. 1106-1115, . (11/00683-5)
BONFANTE, RICARDO; NAPIMOGA, MARCELO HENRIQUE; MACEDO, CRISTINA GOMES; ADBALLA, HENRIQUE BALLASSINI; PIERONI, VICTOR; CLEMENTE-NAPIMOGA, JULIANA TRINDADE. The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints. Neuroscience, v. 391, p. 120-130, . (16/16529-9, 14/09975-7, 11/00683-5, 11/18951-6)
MACEDO, C. G.; NAPIMOGA, M. H.; ROCHA-NETO, L. M.; ABDALLA, H. B.; CLEMENTE-NAPIMOGA, J. T.. The role of endogenous opioid peptides in the antinociceptive effect of 15-deoxy(Delta 12,14)-prostaglandin J(2) in the temporomandibular joint. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, v. 110, p. 27-34, . (11/00683-5)
QUINTEIRO, MARIANA SILVA; NAPIMOGA, MARCELO HENRIQUE; MACEDO, CRISTINA GOMES; FREITAS, FABIANA FURTADO; ABDALLA, HENRIQUE BALASSINI; BONFANTE, RICARDO; CLEMENTE-NAPIMOGA, JULIANA TRINDADE. 15-deoxy-Delta(12,14)-prostaglandin J(2) reduces albumin-induced arthritis in temporomandibular joint of rats. European Journal of Pharmacology, v. 740, p. 58-65, . (11/00683-5)

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