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Impact of bone remodeling on calcium mass transfer during hemodialysis: a study in patients with hyperparathyroidism before and after parathyroidectomy

Grant number: 10/20549-9
Support type:Regular Research Grants
Duration: July 01, 2011 - December 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Rosa Maria Affonso Moysés
Grantee:Rosa Maria Affonso Moysés
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Fabiana Giorgeti Graciolli ; Luciene Machado dos Reis ; Patrícia Taschner Goldenstein ; Tatiana Martins Aniteli ; Vanda Jorgetti ; Wagner Vasques Dominguez

Abstract

Chronic renal failure is associated with disturbances in mineral homeostasis due to bone abnormalities related to a positive calcium and phosphorus balance, resulting in higher risk of fractures, vascular calcification and high mortality. In clinical practice, little attention is given to the dialysate composition. Our group recently showed that bone remodeling could affect calcium mass transfer during hemodialysis. However, bone remodeling was then estimated by PTH and osteocalcin. The aim of this study is to analyze the influence of bone remodeling on calcium mass transfer during hemodialysis in patients with hyperparathyroidism pre and post parathyroidectomy. A total of fifteen patients will be selected and all of them will be submitted to a bone biopsy. Total bone osteocalcin will be estimated and biochemical markers of bone remodeling will be measured. Patients will will be submitted to hemodialysis sessions with dialysate calcium of 1.25; 1.5;1.75 mmol/L before parathyroidectomy. Later on, the protocol will be repeated and we will use their previous results as controls. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOLDENSTEIN, PATRICIA TASCHNER; GRACIOLLI, FABIANA GIORGETI; ANTUNES, GISELE LINS; DOMINGUEZ, WAGNER VASQUES; DOS REIS, LUCIENE MACHADO; MOE, SHARON; ELIAS, ROSILENE MOTTA; JORGETTI, VANDA; AFFONSO MOYSES, ROSA MARIA. A prospective study of the influence of the skeleton on calcium mass transfer during hemodialysis. PLoS One, v. 13, n. 7, . (10/20549-9)

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