Advanced search
Start date
Betweenand

Bioactive compounds from medicinal and food plants of the cerrado and Pantanal and their endophytic microbiota

Grant number: 11/00631-5
Support type:Regular Research Grants
Duration: July 01, 2011 - June 30, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Ana Helena Januário
Grantee:Ana Helena Januário
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Assoc. researchers: Fabiano Guimarães Silva ; Lizandra Guidi Magalhães ; Márcio Luís Andrade e Silva ; Marcos Antônio Soares ; Patricia Mendonça Pauletti ; Wilson Roberto Cunha

Abstract

This project intends to realizes comparative chemistry studies of native medicinal and food species from Cerrado and Pantanal Biomes and their endophytic microbiota. The phytochemistry researches will be bioassay-guided by the antimicrobial and schistosomicidal in vitro assays. The antimicrobial activity will be evaluated by diffusion and broth microdilution methods employing different ATCC strains. The schistosomicidal test will be held evaluating the life cycle of Schistosoma mansoni vector. The analytical methodologies will employ chromatography techniques (CC, PTLC, GC-MS, HPLC-DAD). The chemical structures of the isolated compounds will the assign on the bases of 1D and 2D NMR experiments. Additionally, the quantitative chemical study of crude extracts from seedlings obtained in vitro will be done in comparison with native matrices plants crude extracts by HPLC-DAD. Thus, the main goal of this proposal will be identify potential antimicrobial, and schistossomicidal natural compounds, as well as contribute to the ongoing natural products research in the GPNUF laboratory (UNIFRAN) to the human resource formation in various areas of knowledge covered in this multidisciplinary proposal, and to the consolidation of the Post-Graduations Programs involved. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RITA C. N. PEDROSO; LETICIA P. PIMENTA; MARCOS G. TOZATTI; NÚBIA A. A. BRANQUINHO; ALESSANDRA C. B. A. M. HARA; FERNANDO H. L. SILVA; ALAN C. COSTA; FABIANO G. SILVA; CARLOS E. S. MIRANDA; MARCIO L. A. SILVA; et al. Effects of Light Quality and Chemical Elicitors on the Growth Parameters and Rosmarinic Acid Content of in vitro Cultures of Hyptis pectinata (L.) Poit.. Journal of the Brazilian Chemical Society, v. 30, n. 11, p. 2430-2437, . (11/00631-5)
PEDROSO, RITA C. N.; PIMENTA, LETICIA. P.; TOZATTI, MARCOS G.; BRANQUINHO, NUBIA A. A.; HARA, ALESSANDRA C. B. A. M.; SILVA, FERNANDO H. L.; COSTA, ALAN C.; SILVA, FABIANO G.; MIRANDA, CARLOS E. S.; SILVA, MARCIO L. A.; et al. Effects of Light Quality and Chemical Elicitors on the Growth Parameters and Rosmarinic Acid Content of in vitro Cultures of Hyptis pectinata (L.) Poit. Journal of the Brazilian Chemical Society, v. 30, n. 11, SI, p. 2430-2437, . (11/00631-5)
PARPINELLI, BRUNA A. S.; SIQUEIRA, KATIA A.; KELLNER FILHO, LUIS C.; PIMENTA, LETICIA P.; DA COSTA, RICARDO M.; PARREIRA, RENATO L. T.; VENEZIANI, RODRIGO C. S.; ANDRADE E SILVA, MARCIO L.; CUNHA, WILSON R.; PAULETTI, PATRICIA M.; et al. Effect of Endophytic Fungal Associations on the Chemical Profile of in vitro Vochysia divergens Seedlings. Journal of the Brazilian Chemical Society, v. 28, n. 12, p. 2375-2381, . (11/00631-5)
BRUNA A. S. PARPINELLI; KATIA A. SIQUEIRA; LUIS C. KELLNER FILHO; LETÍCIA P. PIMENTA; RICARDO M. DA COSTA; RENATO L. T. PARREIRA; RODRIGO C. S. VENEZIANI; MARCIO L. ANDRADE E SILVA; WILSON R. CUNHA; PATRÍCIA M. PAULETTI; et al. Effect of Endophytic Fungal Associations on the Chemical Profile of in vitroVochysia divergens Seedlings. Journal of the Brazilian Chemical Society, v. 28, n. 12, p. 2375-2381, . (11/00631-5)
PIMENTAA, LETICIA PEREIRA; KELLNER FILHO, LUIS CLADIO; SOARES PARPINELLI, BRUNA ARRUDA; DE SIQUEIRA, KATIA APARECIDA; SOARES, MARCOS ANTONIO; ANDRADE E SILVA, MARCIO LUIS; CUNHA, WILSON ROBERTO; PAULETTI, PATRICIA MENDONCA; JANUARIO, ANA HELENA. DEVELOPMENT AND VALIDATION OF AN HPLC-DAD ANALYTICAL METHOD TO QUANTIFY 5-METHOXYFLAVONES IN METHANOLIC EXTRACTS OF Vochysia divergens POHL CULTURED UNDER STRESS CONDITIONS. Química Nova, v. 40, n. 9, p. 971-975, . (13/15774-1, 11/00631-5, 13/22030-9, 16/08057-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.