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Acquisition of a confocal microscope for the objective evaluation of markers in anatomical pathology

Grant number: 09/54204-0
Support type:Multi-user Equipment Program
Duration: August 01, 2010 - July 31, 2012
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Fernando Augusto Soares
Grantee:Fernando Augusto Soares
Home Institution: Hospital A C Camargo. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Type of equipment: Tipo de Equipamento Multiusuário não informado
Manufacturer: Fabricante não informado
Model: Modelo não informado

Abstract

One of the most powerful molecular pathology tools used in oncology is the identification of markers of the development, progression, and biological behavior of tumors, markers that can also predict the treatment response. Although the investigation of gene expression has identified a large number of genes related to these biological processes, those findings need to be validated. One of the most commonly used methods is the identification of transcripts and proteins by in situ hybridization, immunohistochemistry or immunofluorescence. These methods are extremely valuable but sometimes lack objective analysis. The identification of markers can reveal anomalous intracellular localizations that can be related to their intrinsic activity, just as the relationship between two markers in a signaling pathway can be important for understanding cell function. Major technological advances have been made in the objective analysis of the localization of relationships between two or more markers, as well as in the recognition of cellular colocalization, by confocal microscopy. This request aims to add quality to anatomopathological research projects at various facilities by acquiring a nextgeneration confocal microscope. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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