Effects of arylpirazole derivates (glucocorticoid receptor modulators) on skeletal muscle atrophy

Abstract

Glucorticoids, have been largely used as antinflammatory and immunosupressor agents in the control of inflammatory related disorders. Artrite, asma, vascular disease, alergies, skin diseases, transpants are among the most common conditions in which glucorticoids are systematically used. Although indubitably efficient, collateral effects emerge, significantly affecting quality of life. Therefore the development of new compounds that maximize therapeutic effects and minimize collateral effects is of obvious benefit. New compounds named L5 and L7 (glucorticoid analogs and derivate from arylpyrazole) have been developed and seem to retain potent antinflammatory effects. Since glucorticoids have a notorious effect upon skeletal muscle mass loss, the aim of the present study was to investigate the impact of such compounds in structural, functional and molecular aspects of skeletal muscle. (AU)