Research Grants 10/19916-7 - Síndrome de Marfan, Fator de crescimento transformador beta - BV FAPESP
Advanced search
Start date
Betweenand

Evaluation on elastic fiber synthesis in cell culture obtained from fibrillin-1 defficient mice: Losartan's effect studies

Grant number: 10/19916-7
Support Opportunities:Regular Research Grants
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Claudio Chrysostomo Werneck
Grantee:Claudio Chrysostomo Werneck
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Cristina Pontes Vicente ; Guilherme Gambogi Braga

Abstract

Fibrillin-1 is an important microfibril network component. Microfibrils are present in elastic fiber responsible for resilience and elastic properties from structures like lungs, skin and large vessels. Mutations in Fibrillin-1 gene are associated with Marfan's Syndrome. Marfan's Syndrome patients shown many different clinical manifestations in lungs, cardiovascular tract and eyes tissues. Marfan's models have been created to get better insights about this disease development. Recent studies from mice models have suggested an important role to unbalanced TGF beta activity promoting almost whole alterations found in those mice which might be rescued by losartan treatment. Our main goal is evaluate elastic fiber formation in cell culture obtained from fibrillin-1 defficient mice and verify TGF-beta expression levels as well as losartan's treatment effect on those cells. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VASSEQUI-SILVA, TALLITA; PEREIRA, DANIELLE SOUSA; NERY DIEZ, ANA CLAUDIA C.; BRAGA, GUILHERME G.; GODOY, JULIANA A.; MENDES, CAMILA B.; DOS SANTOS, LEONARDO; KRIEGER, JOSE E.; ANTUNES, EDSON; COSTA, FABIO T. M.; et al. Losartan and captopril treatment rescue normal thrombus formation in microfibril associated glycoprotein-1 (MAGP1) deficient mice. THROMBOSIS RESEARCH, v. 138, p. 7-15, . (10/19916-7, 12/23640-2)
DAMICO, DANIELA C. S.; VASSEQUI-SILVA, T.; TORRES-HUACO, F. D.; NERY-DIEZ, A. C. C.; DE SOUZA, R. C. G.; DA SILVA, S. L.; VICENTE, C. P.; MENDES, C. B.; ANTUNES, E.; WERNECK, C. C.; et al. LmrTX, a basic PLA(2) (D49) purified from Lachesis muta rhombeata snake venom with enzymatic-related antithrombotic and anticoagulant activity. Toxicon, v. 60, n. 5, p. 773-781, . (10/19916-7, 09/02299-8)
CARNEIRO, GIANE D.; GODOY, JULIANA A. P.; WERNECK, CLAUDIO C.; VICENTE, CRISTINA P.. Differentiation of C57/BL6 mice bone marrow mononuclear cells into early endothelial progenitors cells in different culture conditions. Cell Biology International, v. 39, n. 10, p. 1138-1150, . (10/19916-7, 12/23640-2)
ANTONIELLIS SILVEIRA, ANGELICA APARECIDA; DOMINICAL, VENINA MARCELA; ALMEIDA, CAMILA BONONI; CHWEIH, HANAN; FERREIRA, JR., WILSON ALVES; VICENTE, CRISTINA PONTES; MARANHAO COSTA, FABIO TRINDADE; WERNECK, CLAUDIO C.; COSTA, FERNANDO FERREIRA; CONRAN, NICOLA. TNF induces neutrophil adhesion via formin-dependent cytoskeletal reorganization and activation of beta-integrin function. Journal of Leukocyte Biology, v. 103, n. 1, p. 87-98, . (12/22048-2, 10/19916-7, 14/19173-5)
ANTONIELLIS SILVEIRA, ANGELICA APARECIDA; DOMINICAL, VENINA MARCELA; VITAL, DAIANA MORELLI; FERREIRA, JR., WILSON ALVES; MARANHAO COSTA, FABIO TRINDADE; WERNECK, CLAUDIO C.; COSTA, FERNANDO FERREIRA; CONRAN, NICOLA. Attenuation of TNF-induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho-GTPase activity, p50 activity and morphological changes. International Immunopharmacology, v. 58, p. 160-165, . (12/22048-2, 10/19916-7, 14/19173-5)

Please report errors in scientific publications list using this form.
X

Report errors in this page


Error details: