Advanced search
Start date
Betweenand

Neural mechanisms involved in expiratory rhythm generator: possible involvement of the retrotrapezoid nucleus and the parafacial region

Abstract

The eupnoeic pattern of respiration consists of three phases: inspiration, post-inspiration (passive expiration, stage 1) and stage 2 of expiration. These studies demonstrated that, during respiration, phasic discharges are generated within the ventral respiratory column without the need for peripheral feedback, involving a neuronal network co-ordinated by synaptic interactions (Smith and cols., 1991) that was called ventral respiratory column. Moreover the neural mechanisms for respiratory control are carefully organized by a complex neuron system localized into the medulla oblongata. This system is highly sensitive to CO2 and maintains the CO2 and O2 in the blood into physiological level, controlling the ventilation cycle by cycle. During breathing at rest, air is expired passively by recoil forces. Augmenting expiratory activity during the second phase of expiration (E2) is always present in the brainstem during eupnoea. An expressed phasic expiratory activity in this motor outflow is observed only during increased ventilatory demand such as during exercise in man (Abraham and cols., 2002), hipercapnia or hypoxia in the cat (Fregosi and Bartlett, 1988, Fregosi, 1994, Iizuka and Fregosi, 2007). The origins and mechanisms of generation of this late expiratory activity remain poorly understood and several currently proposed concepts appear controversial. This question constitutes in one of the aims of this project. Recent evidences suggest the involvement of chemosensitive neurons of the retrotrapezoid nucleus (RTN) in the control of expiratory activity of premotor neurons of the caudal ventral respiratory group. In this way, it is important to investigate a real connection between RTN and the caudal ventral respiratory group neurons and, if it really exists, what are the physiological conditions in which such pathway emerges. In this study, we will use anatomical and electrophysiological approaches to investigate the existence of a projection from RTN to caudal ventral respiratory group neurons and the phenotype of the neurotransmitters involved in this projection. We also will study the involvement of the RTN neurons on the activation of caudal ventral respiratory group neurons. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, TALITA M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Acute hypoxia activates hypothalamic paraventricular nucleus-projecting catecholaminergic neurons in the C1 region. Experimental Neurology, v. 285, n. A, p. 1-11, . (13/10573-8, 13/00401-5, 10/09776-3, 14/22406-1)
MULKEY, DANIEL K.; HAWKINS, VIRGINIA E.; HAWRYLUK, JOANNA M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; TZINGOUNIS, ANASTASIOS V.. Molecular underpinnings of ventral surface chemoreceptor function: focus on KCNQ channels. JOURNAL OF PHYSIOLOGY-LONDON, v. 593, n. 5, p. 1075-1081, . (09/54888-7, 13/10573-8, 10/09776-3)
HAWKINS, VIRGINIA E.; HAWRVLUK, JOANNA M.; TAKAKURA, ANA C.; TZINGOUNIS, ANASTASIOS V.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. HCN channels contribute to serotonergic modulation of ventral surface chemosensitive neurons and respiratory activity. Journal of Neurophysiology, v. 113, n. 4, p. 1195-1205, . (09/54888-7, 13/10573-8, 10/09776-3)
WENKER, IAN C.; SOBRINHO, CLEYTON R.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. P2Y1 Receptors Expressed by C1 Neurons Determine Peripheral Chemoreceptor Modulation of Breathing, Sympathetic Activity, and Blood Pressure. Hypertension, v. 62, n. 2, p. 263-273, . (10/19336-0, 10/09776-3, 11/13462-7)
BARNA, B. F.; TAKAKURA, A. C.; MOREIRA, T. S.. PONTOMEDULLARY AND HYPOTHALAMIC DISTRIBUTION OF FOS-LIKE IMMUNOREACTIVE NEURONS AFTER ACUTE EXERCISE IN RATS. Neuroscience, v. 212, p. 120-130, . (10/09776-3, 10/19336-0)
FAVERO, MICHELE T.; TAKAKURA, ANA C.; DE PAULA, PATRICIA M.; COLOMBARI, EDUARDO; MENANI, JOSE V.; MOREIRA, THIAGO S.. Chemosensory control by commissural nucleus of the solitary tract in rats. Respiratory Physiology & Neurobiology, v. 179, n. 2-3, p. 227-234, . (10/09776-3)
TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Contribution of excitatory amino acid receptors of the retrotrapezoid nucleus to the sympathetic chemoreflex in rats. Experimental Physiology, v. 96, n. 10, p. 989-999, . (10/09776-3)
WENKER, IAN C.; SOBRINHO, CLEYTON R.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling. JOURNAL OF PHYSIOLOGY-LONDON, v. 590, n. 9, p. 2137-2150, . (10/19336-0, 10/09776-3, 11/13462-7)
SILVA, JOSIANE N.; LUCENA, ELVIS V.; SILVA, TALITA M.; DAMASCENO, ROSELIA S.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. INHIBITION OF THE PONTINE KOLLIKER-FUSE NUCLEUS REDUCES GENIOGLOSSAL ACTIVITY ELICITED BY STIMULATION OF THE RETROTRAPEZOID CHEMORECEPTOR NEURONS. Neuroscience, v. 328, p. 9-21, . (10/09776-3, 10/15692-7, 12/16166-2, 09/54888-7, 13/00401-5, 13/10573-8, 12/03568-5)
MOREIRA, THIAGO S.; WENKER, IAN C.; SOBRINHO, CLEYTON R.; BARNA, BARBARA F.; TAKAKURA, ANA C.; MULKEY, DANIEL K.. Independent purinergic mechanisms of central and peripheral chemoreception in the rostral ventrolateral medulla. JOURNAL OF PHYSIOLOGY-LONDON, v. 593, n. 5, p. 1067-1074, . (10/09776-3, 14/04866-5, 09/54888-7, 11/13462-7, 13/10573-8, 13/02350-9, 12/10337-0)
BARNA, B. F.; TAKAKURA, A. C.; MULKEY, D. K.; MOREIRA, T. S.. Purinergic receptor blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats. ACTA PHYSIOLOGICA, v. 217, n. 1, p. 80-93, . (09/54888-7, 12/10337-0, 13/10573-8, 10/09776-3)
DAMASCENO, ROSELIA S.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Respiratory and sympathetic chemoreflex regulation by Kolliker-Fuse neurons in rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 467, n. 2, p. 231-239, . (10/09776-3, 10/19336-0, 10/15692-7)
SOBRINHO, CLEYTON R.; WENKER, IAN C.; POSS, ERIN M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. Purinergic signalling contributes to chemoreception in the retrotrapezoid nucleus but not the nucleus of the solitary tract or medullary raphe. JOURNAL OF PHYSIOLOGY-LONDON, v. 592, n. 6, p. 1309-1323, . (10/19336-0, 10/09776-3, 11/13462-7)
TAKAKURA, ANA C.; MOREIRA, THIAGO S.; BORELLA, THAIS L.; PAULIN, RENATA F.; COLOMBARI, DEBORA S. A.; DE LUCA, JR., LAURIVAL A.; COLOMBARI, EDUARDO; MENANI, JOSE V.. Central mechanisms involved in pilocarpine-induced pressor response. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 164, n. 1-2, p. 34-42, . (10/09776-3, 07/06430-6)
TOTOLA, L. T.; ALVES, T. B.; TAKAKURA, A. C.; FERREIRA-NETO, H. C.; ANTUNES, V. R.; MENANI, J. V.; COLOMBARI, E.; MOREIRA, T. S.. COMMISSURAL NUCLEUS OF THE SOLITARY TRACT REGULATES THE ANTIHYPERTENSIVE EFFECTS ELICITED BY MOXONIDINE. Neuroscience, v. 250, p. 80-91, . (10/09776-3, 10/19336-0, 09/54888-7, 11/50770-1, 11/11934-9)
TAKAKURA, ANA C.; MOREIRA, THIAGO S.; DE PAULA, PATRICIA M.; MENANI, JOSE V.; COLOMBARI, EDUARDO. Control of breathing and blood pressure by parafacial neurons in conscious rats. Experimental Physiology, v. 98, n. 1, p. 304-315, . (09/54888-7, 10/19336-0, 10/09776-3)
TAXINI, C. L.; TAKAKURA, A. C.; GARGAGLIONI, L. H.; MOREIRA, T. S.. CONTROL OF THE CENTRAL CHEMOREFLEX BY A5 NORADRENERGIC NEURONS IN RATS. Neuroscience, v. 199, p. 177-186, . (10/15501-7, 10/09776-3, 10/19336-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.