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Prevalence and investigation of the HCMV role in the oncomodulation of cerebral tumors


Human cytomegalovirus (HCMV) is an important viral pathogen that causes a variety of diseases in imunocompromised individuals and newborns that can culminate in death. Recent evidences indicate that HCMV is involved in tumor progression. Studies demonstrated that the viral DNA and proteins are present in many types of cancer tissues; viral proteins are able to interfere with cell cycle, apoptosis and the immune system. In addition, there are indications that the infection of tumor cells by HCMV increases their malignity. These evidences lead to the creation of the term oncomodulation, defined as the ability of the virus to promote tumor progression. The studies of the HCMV role in the process of tumor malignity are rapidly advancing and a better understanding of the oncomodulation phenomenon is essential to clarify the participation of HCMV in malignity and for the determination of specific viral proteins that can be therapeutic targets in certain tumors types. This project aims the detection HCMV viral replication in brain tumors, as well as the establishment of tumor cell lines and inhibition of the expression of specific viral proteins that are likely involved in tumor malignity to further verify their effect in cell proliferation. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, CLAUDIA JANUARIO; STANGHERLIN, LUCAS MATHEUS; FIGUEIREDO, EBERVAL GADELHA; CORREA, CLEMAR; TEIXEIRA, MANOEL JACOBSEN; CARLAN DA SILVA, MARIA CRISTINA. High Prevalence of HCMV and Viral Load in Tumor Tissues and Peripheral Blood of Glioblastoma Multiforme Patients. Journal of Medical Virology, v. 86, n. 11, p. 1953-1961, . (10/14830-7)

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