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Possible drug interaction between clopidogrel and ranitidin or omeprazol in patients with stable coronary artery disease: a comparative study


Study population: 100 pacientes com Doença Arterial Coronária crônica selecionados do ambulatório da UCCA 100 patients with Stable Coronary Artery Disease from the Heart Institute Inclusion Criteria: Age > 18 years old; coronary artery disease, defined as previous myocardial infarction and/or coronary angioplasty and/or CABG surgery and/or coronariography showing obstruction of at least 50 % in one of major epicardial vesses; in use of ASA. Exclusion Criteria: Use in the last 7 days of any other antiplatelet drug beside ASA or oral anticoagulant; previous utilization of PPI or ranitidine in the last 7 days before randomization; active bleeding; pregnancy or woman of childbearing age without contraceptive method; hemoglobin < 10 g/dL or hematocrit < 30 %, hematocrit > 50 %, platelets < 100.000/mm3 or > 500.000/mm3; creatinin clearance < 50 ml/minute; percutaneous coronary intervention (PCI) in the last 30 days before randomization (or PCI on the last year when drug-eluted stents are used); CABG surgery on the last 90 days; acute coronay syndrome in the last 60 days; malignant neoplasm;active peptic ulcer disease on the last 60 days or digestive bleeding any time in life; known allergy to the drugs clopidogrel, ranitidine or omeprazole; refuse to participate in the study. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE MENDONCA FURTADO, REMO HOLANDA; GIUGLIANO, ROBERT PATRICK; CASSARO STRUNZ, CELIA MARIA; CAVALHEIRO FILHO, CYRILLO; FRANCHINI RAMIRES, JOSE ANTONIO; KALIL FILHO, ROBERTO; LEMOS NETO, PEDRO ALVES; PEREIRA, ALEXANDRE COSTA; ROCHA, TANIA RUBIA; FREIRE, BEATRIZ TONON; et al. Drug Interaction Between Clopidogrel and Ranitidine or Omeprazole in Stable Coronary Artery Disease: A Double-Blind, Double Dummy, Randomized Study. American Journal of Cardiovascular Drugs, v. 16, n. 4, p. 275-284, . (10/16324-1)

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