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Mitochondrial bioenergetics, ion transport, redox state and DNA metabolism

Abstract

Changes in mitochondrial energy metabolism, ion transport, mtDNA metabolism and redox balance are associated with a variety of physiological and pathological conditions including aging, obesity, heart attack and the toxicity of environmental contaminants. The central aim of this project is to analyze the role of alterations in mitochondrial ion transport, energy and DNA metabolism and/or redox state in these physio-pathological conditions. We believe that a better understanding of the molecular mechanisms underlying the mitochondrial involvement in these processes will allow the development of interventions capable of controlling these unwelcome mitochondrial and cellular effects in pathological processes of strong impact in human health. (AU)

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Scientific publications (30)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATEUS PRATES MORI; NADJA CRISTHINA DE SOUZA-PINTO. PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 1, . (17/04372-0, 16/15407-7, 10/51906-1)
SOLTYS, DANIELA TATHIANA; MARTINS PEREIRA, CAROLINA PARGA; ISHIBE, GABRIELA NAOMI; DE SOUZA-PINTO, NADJA CRISTHINA. Effects of post mortem interval and gender in DNA base excision repair activities in rat brains. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v. 776, p. 6-pg., . (08/57721-3, 13/07937-8, 10/51906-1)
RUAS, JULIANA S.; SIQUEIRA-SANTOS, EDILENE S.; AMIGO, IGNACIO; RODRIGUES-SILVA, ERIKA; KOWALTOWSKI, ALICIA J.; CASTILHO, ROGER F.. Underestimation of the Maximal Capacity of the Mitochondrial Electron Transport System in Oligomycin-Treated Cells. PLoS One, v. 11, n. 3, . (12/51288-1, 10/51906-1, 11/50400-0, 13/07937-8)
CAMPOS, JULIANE C.; QUELICONI, BRUNO B.; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; DOURADO, PAULO M. M.; ANDRES, ALLEN M.; JANNIG, PAULO R.; GOMES, KATIA M. S.; ZAMBELLI, VANESSA O.; ROCHA-RESENDE, CIBELE; et al. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. AUTOPHAGY, v. 13, n. 8, p. 1304-1317, . (10/51906-1, 10/00028-4, 09/12349-2, 15/20783-5, 12/05765-2, 16/01633-5)
FORNI, MARIA FERNANDA; PELOGGIA, JULIA; BRAGA, TARCIO T.; ORTEGA CHINCHILLA, JESUS EDUARDO; SHINOHARA, JORGE; NAVAS, CARLOS ARTURO; SARAIVA CAMARA, NIELS OLSEN; KOWALTOWSKI, ALICIA J.. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin. CELL REPORTS, v. 20, n. 11, p. 2678-2692, . (10/51906-1, 14/17270-3, 12/02270-2, 13/04871-6, 14/16320-7, 13/07937-8)
SANTOS, CARLA SANTANA; KOWALTOWSKI, ALICIA J.; BERTOTTI, MAURO. Single Cell Oxygen Mapping (SCOM) by Scanning Electrochemical Microscopy Uncovers Heterogeneous Intracellular Oxygen Consumption. SCIENTIFIC REPORTS, v. 7, . (14/22396-6, 10/51906-1, 13/07937-8)
SARAVIA, L. P. H.; ANANDHAKUMAR, S.; PARUSSULO, A. L. A.; MATIAS, T. A.; CALDEIRA DA SILVA, C. C.; KOWALTOWSKI, A. J.; ARAKI, K.; BERTOTTI, M.. Development of a tetraphenylporphyrin cobalt (II) Modified glassy carbon electrode to monitor oxygen consumption in biological samples. Journal of Electroanalytical Chemistry, v. 775, p. 72-76, . (12/20676-6, 14/15215-5, 10/51906-1)
MORI, MATEUS P.; COSTA, RUTE A. P.; SOLTYS, DANIELA T.; FREIRE, THIAGO DE S.; ROSSATO, FRANCO A.; AMIGO, IGNACIO; KOWALTOWSKI, ALICIA J.; VERCESI, ANBAL E.; DE SOUZA-PINTO, NADJA C.. Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress. SCIENTIFIC REPORTS, v. 7, . (12/11889-6, 08/57952-5, 10/51906-1, 11/50400-0, 08/57721-3, 06/59786-0, 13/07937-8)
FERREIRA, JULIO C. B.; CAMPOS, JULIANE C.; QVIT, NIR; QI, XIN; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; QUELICONI, BRUNO B.; DISATNIK, MARIE-HELENE; DOURADO, PAULO M. M.; et al. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. NATURE COMMUNICATIONS, v. 10, . (10/00028-4, 15/22814-5, 17/16694-2, 17/11142-1, 12/05765-2, 10/51906-1, 17/16540-5, 09/12349-2, 16/01633-5, 16/09611-0, 15/20783-5)
ABRANTES, ALINE B. DE P.; DIAS, GUSTAVO C.; SOUZA-PINTO, NADJA C.; BAPTISTA, MAURICIO S.. p53-Dependent and p53-Independent Responses of Cells Challenged by Photosensitization. Photochemistry and Photobiology, v. 95, n. 1, p. 355-363, . (14/18123-4, 10/51906-1, 17/04372-0, 12/50680-5, 13/07937-8)
GOMES, KATIA M. S.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; RIBEIRO, MARCIO A. C.; CAMPOS, JULIANE C.; DOURADO, PAULO M.; KOWALTOWSKI, ALICIA J.; MOCHLY-ROSEN, DARIA; FERREIRA, JULIO C. B.. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: Benefits of Alda-1. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 179, p. 129-138, . (12/05765-2, 10/51906-1, 13/07937-8)
SARAVIA, L. P. H.; ANANDHAKUMAR, S.; PARUSSULO, A. L. A.; MATIAS, T. A.; CALDEIRA DA SILVA, C. C.; KOWALTOWSKI, A. J.; ARAKI, K.; BERTOTTI, M.. Development of a tetraphenylporphyrin cobalt (II) Modified glassy carbon electrode to monitor oxygen consumption in biological samples. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 775, p. 5-pg., . (10/51906-1, 14/15215-5, 12/20676-6)
MORI, MATEUS PRATES; DE SOUZA-PINTO, NADJA CRISTHINA. PPRC1, but not PGC-1 alpha, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 1, . (16/15407-7, 17/04372-0, 10/51906-1)
ERTUZUN, TUGCE; SEMERCI, ASLI; CAKIR, MEHMET EMIN; EKMEKCIOGLU, AYSEGUL; GOK, MEHMET OGUZ; SOLTYS, DANIELA T.; DE SOUZA-PINTO, NADJA C.; SEZERMAN, UGUR; MUFTUOGLU, MELTEM. Investigation of base excision repair gene variants in late-onset Alzheimer's disease. PLoS One, v. 14, n. 8, . (17/04372-0, 10/51906-1)
GARCIA, BRUNA M.; MACHADO, THIAGO S.; CARVALHO, KAREN F.; NOLASCO, PATRICIA; NOCITI, RICARDO P.; DEL COLLADO, MAITE; CAPO BIANCO, MARIA J. D.; GREJO, MATEUS P.; AUGUSTO NETO, JOSE DJACI; SUGIYAMA, FABRICIA H. C.; et al. Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. MOLECULAR HUMAN REPRODUCTION, v. 26, n. 12, p. 938-952, . (10/51906-1, 17/05899-2, 17/04372-0, 18/20028-0, 18/06119-3, 16/11935-9, 09/54035-4, 12/50231-6, 16/11942-5)
AMIGO, IGNACIO; MENEZES-FILHO, SERGIO LUIZ; LUEVANO-MARTINEZ, LUIS ALBERTO; CHAUSSE, BRUNO; KOWALTOWSKI, ALICIA J.. Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. AGING CELL, v. 16, n. 1, p. 73-81, . (10/51906-1, 12/51288-1)
QUELICONI, BRUNO B.; KOWALTOWSKI, ALICIA J.; GOTTLIEB, ROBERTA A.. Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy. PLoS One, v. 11, n. 12, . (10/51906-1, 13/07937-8, 13/07292-7)
AMIGO, IGNACIO; DA CUNHA, FERNANDA M.; FORNI, MARIA FERNANDA; GARCIA-NETO, WILSON; KAKIMOTO, PAMELA A.; LUEVANO-MARTINEZ, LUIS A.; MACEDO, FELIPE; MENEZES-FILHO, SERGIO L.; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Mitochondrial form, function and signalling in aging. Biochemical Journal, v. 473, n. 20, p. 3421-3449, . (15/15526-3, 10/51906-1, 14/17270-3, 13/04919-9, 15/25776-7, 13/07937-8)
SILVA-PORTELA, RITA C. B.; CARVALHO, FABIOLA M.; PEREIRA, CAROLINA P. M.; DE SOUZA-PINTO, NADJA C.; MODESTI, MAURO; FUCHS, ROBERT P.; AGNEZ-LIMA, LUCYMARA F.. ExoMeg1: a new exonuclease from metagenomic library. SCIENTIFIC REPORTS, v. 6, . (10/51906-1, 08/57721-3)
FORNI, MARIA FERNANDA; CHAUSSE, BRUNO; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Bioenergetic profiling in the skin. EXPERIMENTAL DERMATOLOGY, v. 25, n. 2, p. 147-148, . (10/51906-1, 13/04871-6, 13/07937-8, 14/17270-3)
KAKIMOTO, PAMELA A.; KOWALTOWSKI, ALICIA J.. Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance. REDOX BIOLOGY, v. 8, p. 216-225, . (10/51906-1, 13/07937-8, 13/03556-0)
MUFTUOGLU, MELTEM; MORI, MATEUS P.; DE SOUZA-PINTO, NADJA C.. Formation and repair of oxidative damage in the mitochondrial DNA. MITOCHONDRION, v. 17, p. 164-181, . (10/51906-1)
ROUBICEK, DEBORAH A.; DE SOUZA-PINTO, NADJA C.. Mitochondria and mitochondrial DNA as relevant targets for environmental contaminants. Toxicology, v. 391, p. 100-108, . (10/51906-1, 13/07937-8)
MAGDALON, JULIANA; CHIMIN, PATRICIA; BELCHIOR, THIAGO; NEVES, RODRIGO X.; VIEIRA-LARA, MARCEL A.; ANDRADE, MAYNARA L.; FARIAS, TALITA S.; BOLSONI-LOPES, ANDRESSA; PASCHOAL, VIVIAN A.; YAMASHITA, ALEX S.; et al. Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1861, n. 5, p. 430-438, . (10/51906-1, 11/03972-8, 12/25317-4, 15/19530-5, 13/14203-0, 09/15354-7)
LUEVANO-MARTINEZ, LUIS ALBERTO; FORNI, MARIA FERNANDA; DOS SANTOS, VALQUIRIA TIAGO; SOUZA-PINTO, NADJA C.; KOWALTOWSKI, ALICIA J.. Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, v. 1847, n. 6-7, p. 587-598, . (10/51906-1, 10/18254-0, 13/04919-9, 13/04871-6, 13/07937-8)
SOLTYS, DANIELA TATHIANA; MARTINS PEREIRA, CAROLINA PARGA; ISHIBE, GABRIELA NAOMI; DE SOUZA-PINTO, NADJA CRISTHINA. Effects of post mortem interval and gender in DNA base excision repair activities in rat brains. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v. 776, n. SI, p. 48-53, . (10/51906-1, 08/57721-3, 13/07937-8)
FREIRE, T. S.; MORI, M. P.; MIRANDA, J. N. F. A.; MUTA, L. Y. M.; MACHADO, F. T.; MORENO, N. C.; SOUZA-PINTO, N. C.. Increased H2O2 levels and p53 stabilization lead to mitochondrial dysfunction in XPC-deficient cells. Carcinogenesis, v. 42, n. 11, p. 1380-1389, . (17/04372-0, 18/04471-1, 10/51906-1, 18/26555-2, 19/00480-9, 16/15407-7)
FORNI, MARIA FERNANDA; PELOGGIA, JULIA; TRUDEAU, KYLE; SHIRIHAI, ORIAN; KOWALTOWSKI, ALICIA J.. Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells, v. 34, n. 3, p. 743-755, . (10/51906-1, 13/04871-6, 13/07937-8, 14/17270-3)
MORI, MATEUS PRATES; DE SOUZA-PINTO, NADJA CRISTHINA. PPRC1, but not PGC-1 alpha, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts. GENETICS AND MOLECULAR BIOLOGY, v. 43, p. 10-pg., . (16/15407-7, 10/51906-1, 17/04372-0)
AMIGO, IGNACIO; DA CUNHA, FERNANDA M.; FORNI, MARIA FERNANDA; GARCIA-NETO, WILSON; KAKIMOTO, PAMELA A.; LUEVANO-MARTINEZ, LUIS A.; MACEDO, FELIPE; MENEZES-FILHO, SERGIO L.; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Mitochondrial form, function and signalling in aging. Biochemical Journal, v. 473, p. 29-pg., . (13/07937-8, 13/04919-9, 15/15526-3, 14/17270-3, 10/51906-1, 15/25776-7)

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