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Isolation and morphological, biological and molecular characterization and multigenes phylogeography from species causing visceral leishmaniasis

Abstract

Leishmaniasis is a geographically widespread severe disease, with a increasing incidence of two million cases per year and 350 million people at risck. The causative agents are species of Leishmania, a protozoan flagellate. Visceral leishmaniasis, the most severe form of disease, lethal if untreated, is caused by species of the Leishmania donovani complex. Is a zoonotic disease and the domestic dogs and Lutzomyia longipalpis are the primary reservoir and vector in New World, respectively. Is not yet clear the role of wild mammals in the cycle. Through molecular markers was shown a biogeographic pattern in samples from biogeography, and general epidemiological characteristics and the relationship between vertebrate and invertebrate hosts generating data for understanding the evolutionary history of this parasite in the New world. The samples will be collected in different areas of Atlantic Forest, Pantanal, Amazon and Caatinga at different time of the year. In each area will be trapped domestic dogs and sylvatic animals (rodents, marsupials and bats) and obtained blood samples for the isolation and molecular characterization through traditional and new phylogenetic markers (SSU rDNA, ITS1 and ITS2 rDNA, cytochrome b, gGAPDH, cathepsin L-like, gp63, histone H2A, elongation factor 1α. and heat-shock protein) and population polymorphic markers (RAPD and microsatellites ). (AU)

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VEICULO: TITULO (DATA)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA, ANDREA P.; NUNES, PABLO HENRIQUE; SANTOS LEITE, BEATRIZ HELENA; FERREIRA, JULIANA ISABEL G. DA S.; TONHOSOLO, RENATA; DA ROSA, ADRIANA RUCKERT; DA ROCHA, PATRICIO ADRIANO; AIRES, CAROLINE COTRIM; GENNARI, SOLANGE MARIA; MARCILI, ARLEI. Diversity of bats trypanosomes in hydroeletric area of Belo Monte in Brazilian Amazonia. Acta Tropica, v. 164, p. 185-193, . (11/19853-8, 11/15311-6, 10/50886-7)
MARCILI, ARLEI; SPERANCA, MARCIA AP.; DA COSTA, ANDREA P.; MADEIRA, MARIA DE F.; SOARES, HERBERT S.; SANCHES, CAMILA DE O. C. C.; ACOSTA, IGOR DA C. L.; GIROTTO, ALINE; MINERVINO, ANTONIO H. H.; HORTA, MAURICIO C.; et al. Phylogenetic relationships of Leishmania species based on trypanosomatid barcode (SSU rDNA) and gGAPDH genes: Taxonomic revision of Leishmania (L.) infantum chagasi in South America. INFECTION GENETICS AND EVOLUTION, v. 25, p. 44-51, . (11/19853-8, 11/15311-6, 12/20221-9, 10/50886-7)
LIMA ACOSTA, IGOR DA CUNHA; DA COSTA, ANDREA PEREIRA; NUNES, PABLO HENRIQUE; NAEGELI GONDIM, MARIA FERNANDA; GATTI, ANDRESSA; ROSSI, JR., JOAO LUIZ; GENNARI, SOLANGE MARIA; MARCILI, ARLEI. Morphological and molecular characterization and phylogenetic relationships of a new species of trypanosome in Tapirus terrestris (lowland tapir), Trypanosoma terrestris sp nov., from Atlantic Rainforest of southeastern Brazil. PARASITES & VECTORS, v. 6, . (11/19853-8, 11/15311-6, 10/50886-7)
DA COSTA, ANDREA PEREIRA; COSTA, FRANCISCO BORGES; SOARES, HERBERT SOUSA; RAMIREZ, DIEGO GARCIA; ARAUJO, ANDREINA DE CARVALHO; GIULI DA SILVA FERREIRA, JULIANA ISABEL; TONHOSOLO, RENATA; DIAS, RICARDO AUGUSTO; GENNARI, SOLANGE MARIA; MARCILI, ARLEI. Environmental Factors and Ecosystems Associated with Canine Visceral Leishmaniasis in Northeastern Brazil. VECTOR-BORNE AND ZOONOTIC DISEASES, v. 15, n. 12, p. 765-774, . (11/19853-8, 10/50886-7)
VERDE OLIVEIRA ROCHA, ANA VITORIA; SODRE MORENO, BRENDA FERNANDA; CABRAL, ALINE DINIZ; LOUZEIRO, NAYARA MENDES; MIRANDA, LEANDRO MACEDO; BRANDAO DOS SANTOS, VIVIAN MAGALHAES; COSTA, FRANCISCO BORGES; SEABRA NOGUEIRA, RITA DE MARIA; MARCILI, ARLEI; SPERANCA, MARCIA APARECIDA; et al. Diagnosis and epidemiology of Leishmania infantum in domestic cats in an endemic area of the Amazon region, Brazil. Veterinary Parasitology, v. 273, p. 80-85, . (13/26096-4, 11/00147-6, 16/14514-4, 10/50886-7)
DA SILVA, RYAN EMILIANO; SAMPAIO, BRUNA MATARUCCO; TONHOSOLO, RENATA; RA DA COSTA, ANDREA PEREI; DA SILVA COSTA, LUIZ EDUARDO; AP NIERI-BASTOS, FERNANDA; SPERANCA, MARCIA APARECIDA; MARCILI, ARLEI. Exploring Leishmania infantum cathepsin as a new molecular marker for phylogenetic relationships and visceral leishmaniasis diagnosis. BMC INFECTIOUS DISEASES, v. 19, n. 1, . (10/50886-7)

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