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Search for inhibitors of antioxidante proteins of Xylella fastidiosa

Grant number: 04/07709-6
Support Opportunities:BIOTA-FAPESP Program - Regular Research Grants
Duration: October 01, 2004 - June 30, 2009
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Luis Eduardo Soares Netto
Grantee:Luis Eduardo Soares Netto
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Plants and animals respond to infections by pathogenic agents using among other mechanisms an oxidative burst. In this way, Xylella fastidiosa and other pathogenic agents have to overcome the oxidative burst generated by plants to be successful in the infection. Our objective in this project is the search for potential inhibitors of antioxidant enzymes of Xyllela fastidiosa in banks of extracts and pure compound of plants, microorganisms, marine organisms and other natural sources. Several antioxidant proteins of Xyllela fastidiosa have already been cloned, expressed and purified in my laboratory. In addition, relationships between protein structure and function are being investigated within the Structural Molecular Biology Network (SMOLBnet). (AU)

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