Advanced search
Start date

Assessment of the role of angiotensin II in the cardiovascular effects induced by acute ethanol consumption

Grant number: 10/05815-4
Support Opportunities:Regular Research Grants
Duration: April 01, 2011 - September 30, 2013
Field of knowledge:Biological Sciences - Pharmacology - Cardiorenal Pharmacology
Principal Investigator:Carlos Renato Tirapelli
Grantee:Carlos Renato Tirapelli
Host Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Evelin Capellari Cárnio ; Regina Helena Costa Queiroz


Binge drinking has become usual in our society and is defined as the consumption of high doses of ethanol in a short period of time. Acute ethanol intake induces a transient increase in blood pressure. However, the molecular mediators underlying the cardiovascular effects of acute ethanol intake remain elusive. Acute administration of ethanol induces the generation of reactive oxygen species (ROS) in several tissues. In chronically ethanol-treated rats the initial step associated with cardiovascular dysfunction involves increased ROS generation, being this processes mediated by the NADPH oxidase enzyme. Angiotensin II (Ang II) activates NADPH oxidase in the cardiovascular system and both chronic and acute ingestion of ethanol stimulates the rennin-angiotensin system (RAS). A possible role for MAPKs (Mitogen-Activated Protein Kinases) on the effects of ethanol in the cardiovascular system has been described. Ethanol appears to indirectly activate MAPKs in the cardiovascular system. The MAPKs are activated by several stimuli such as ROS and Ang II. The hypothesis of the present study is that acute ethanol intake stimulates RAS which in turn induces the generation of ROS (via NADPH oxidase) and the activation of MAPKs. This process would induce alterations in vascular reactivity and NO bioavailability as well as a transient increase in blood pressure. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HIPOLITO, ULISSES V.; CALLERA, GLAUCIA E.; SIMPLICIO, JANAINA A.; DE MARTINIS, BRUNO S.; TOUYZ, RHIAN M.; TIRAPELLI, CARLOS R.. Vitamin C prevents the endothelial dysfunction induced by acute ethanol intake. Life Sciences, v. 141, p. 99-107, . (10/05815-4, 10/01383-2)
SIMPLICIO, JANAINA A.; RESSTEL, LEONARDO B.; TIRAPELLI, DANIELA P. C.; D'ORLEANS-JUSTE, PEDRO; TIRAPELLI, CARLOS R.. Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. VASCULAR PHARMACOLOGY, v. 73, p. 124-137, . (10/05815-4, 13/00808-8)
GONZAGA, NATALIA A.; AWATA, WANESSA M. C.; DO VALE, GABRIEL T.; MARCHI, KATIA C.; MUNIZ, JAQUELINE J.; TANUS-SANTOS, JOSE E.; TIRAPELLI, CARLOS R.. Perivascular adipose tissue protects against the vascular dysfunction induced by acute ethanol intake: Role of hydrogen peroxide. VASCULAR PHARMACOLOGY, v. 111, p. 44-53, . (10/05815-4)
PASSAGLIA, PATRICIA; CERON, CARLA S.; MECAWI, ANDRE S.; ANTUNES-RODRIGUES, JOSE; COELHO, EDUARDO B.; TIRAPELLI, CARLOS R.. Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress. VASCULAR PHARMACOLOGY, v. 74, p. 49-59, . (12/10096-2, 10/05815-4)
YOGI, ALVARO; CALLERA, GLAUCIA E.; MECAWI, ANDRE S.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; ANTUNES-RODRIGUES, JOSE; QUEIROZ, REGINA H.; TOUYZ, RHIAN M.; TIRAPELLI, CARLOS R.. Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: A role for angiotensin type 1 receptor. Toxicology and Applied Pharmacology, v. 264, n. 3, p. 470-478, . (10/05815-4)
CERON, CARLA S.; DO VALE, GABRIEL T.; SIMPLICIO, JANAINA A.; PASSAGLIA, PATRICIA; RICCI, STHEFANY T.; TIRAPELLI, CARLOS R.. Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats. DATA IN BRIEF, v. 11, p. 111-116, . (10/05815-4)

Please report errors in scientific publications list using this form.