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Obesity and sex hormones in lung injury

Grant number: 10/51330-2
Support Opportunities:Regular Research Grants
Duration: September 01, 2010 - August 31, 2012
Field of knowledge:Biological Sciences - Pharmacology - General Pharmacology
Convênio/Acordo: King's College London
Principal Investigator:Wothan Tavares de Lima
Grantee:Wothan Tavares de Lima
Principal researcher abroad: Yanira Riffo Vasquez
Institution abroad: King's College London, England
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


There is no general consensus of a positive correlation between high body mass index (BMI) and trauma-induced mortality. Some studies suggest that obese patients are more likely to have a negative outcome from trauma and sepsis because they already constitutively express many of the inflammatory mediators observed in this condition. However, other studies have reported that mortality it is not positively correlated to body mass index (BMI) but it seems to correlate with morbidity. Interestingly, in some studies a negative correlation between mortality and BMI was found, suggesting a protective role of obesity in cases of acute lung injury. Recently, was found that in critically ill patients with acute lung injury, increasing BMI is associated with greater white blood cell counts but not with changes in mortality suggesting an altered innate immune response in these patients. Interestingly, despite the evidence showing the influence of sex hormones or obesity on lung injury and ischemic trauma in general, the interaction between these two factors has been poorly investigated. A recent study has shown a correlation between abdominal adipose mass is associated with an increased risk of myocardial infarct in women but not in men. Conversely, other studies have failed to establish a correlation between gender and ischemic stroke among obese patients. In a cross-sectional study, only obese women with metabolic syndrome have an increased prevalence of coronary artery disease in comparison to obese women with normal metabolism. In addition, obese women with normal metabolism have an increased survival rate in comparison to women with normal BMI, suggesting a protective role for obesity in arterial ischemia In summary, the main experimental aims of this proposal are 1. To investigate the role of female sex hormones in the physiopathology of intestinal I/R in obese mice with or without ovaries (ovariectomized). We will measure inflammatorycell migration and mediator release, lymphocyte populations and function, danger signals release; platelet migration and platelet mediators release. 2- In addition, we will also investigate levels of leptin, glucose and circulating lipids in obese mice depleted of sex hormones by means of ovarian removal (ovariectomy) (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FANTOZZI, EVELYN THAIS; RODRIGUES-GARBIN, SARA; RICARDO-DA-SILVA, FERNANDA YAMAMOTO; OLIVEIRA-FILHO, RICARDO MARTINS; SPINA, DOMENICO; TAVARES-DE-LIMA, WOTHAN; RIFFO-VASQUEZ, YANIRA. Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice. Pulmonary Pharmacology & Therapeutics, v. 49, p. 54-59, . (10/51330-2, 12/50550-4)

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