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Evaluation of Osteoscaf® graft in rabbits maxillary sinus

Grant number: 10/10243-0
Support Opportunities:Regular Research Grants
Duration: October 01, 2010 - September 30, 2012
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Osny Ferreira Júnior
Grantee:Osny Ferreira Júnior
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated researchers:Camila Lopes Cardoso ; Gustavo Pompermaier Garlet


Currently, reconstructive surgery is performed routinely to correct a small or large bone defects previously to implant placement. It is known that the autogenous bone graft is the best for filling bone defects, because it has the ideal characteristics as: osteogenic, osteoinductive and osteoconductive. However it has limitations such as: the need for more surgeries, the morbidity of donor site, and limiting the amount of it. Studies are undertaken in order to obtain material for grafts with ideals biomechanical and osteogenic properties. The Osteoscaf® is a scaffold with similar porosity to human cancellous bone, formed by the union fully resorbable polylactic acid-co-glycolic (APLG) with two phases of calcium phosphate (CaP). The Osteoscaf® has shown bone growth both in vitro and in vivo and offer great potential for application in bioengineering. Some studies in animals have shown biocompatibility, osteoconductive and osteoinductive properties. The aim of this study is to evaluate new bone formation in surgery of maxillary sinus lifting in rabbits using Osteoscaf ® in granulated form and compare it with bone grafts using autogenous iliac crest removed, Bio-Oss ® and BoneCeramic ®. For this experiment will be used 66 adult white rabbits divided into 4 experimental groups analyzed 2, 4 and 8 weeks after graft surgery. All specimens are evaluated qualitatively and quantitatively by computed tomography. 6 specimens per group in each period will be analyzed by conventional optical microscopy and 3 samples per group, will be evaluated by confocal fluorescence microscopy by appointment fluorochrome (tetracycline, calcein and alizarin). In addition, there will be a quantitative expression of genes involved in bone repair [type I collagen, VEGF, osteocalcin (OCN), alkaline phosphatase (ALP) and CBFA-1] in two specimens of each group by RealTimePCR, correlating expression with histological features observed. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMILA L CARDOSO; CLÁUDIA CURRA; PÂMELA L SANTOS; MARIA F.M RODRIGUES; OSNY FERREIRA-JÚNIOR; PAULO S.P DE CARVALHO. Current considerations on bone substitutes in maxillary sinus lifting. Rev. Clin. Periodoncia Implantol. Rehabil. Oral, v. 9, n. 2, p. 102-107, . (10/10243-0)

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