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Relationship between oxidative stress and morphofunctional classes of colorectal carcinoma, assessment by expression of cellular adhesion protein (CEA, E-cadherin, beta-cathenin) and carcinoembryonic antigen dynamics

Grant number: 07/01196-5
Support Opportunities:Regular Research Grants
Duration: July 01, 2008 - December 31, 2010
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Denise Gonçalves Priolli
Grantee:Denise Gonçalves Priolli
Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil


The relationship between carcinoembryonic antigen tissue expression and histological, molecular and genetic alterations in colorectal cancer cases is a matter of much controversy. Colorectal cancer immunohistochemical analyses have demonstrated that increase CEA tissue production seems to be related to antigen-producer larger population cells and loss of cell differentiation and CEA luminal excretion capacity. Studies have demonstrated that secretory dynamic changes have been caused by proteins polarization inversion in neoplastic cells, relating with tumor markers and others cell adhesion proteins like E-cadherin and beta-catenin. It is known that colorectal carcinogenesis initial stage is oxidative stress, thereby causing mutations and distancing from normal cell characteristics and synthesis and excretion protein cell capacity modification. However, the relation between DNA oxidative stress and morphofunctional cell modifications, translated by colon cells phenotypic characteristics changes, is not established. The analyze of relation between DNA oxidative stress and morphologic and functional expressions in colorectal cancer, assessment by adhesion proteins cell expression (morphologic characteristic) and CEA dynamic (functional characteristic) in colorectal cancer could contribute to get better colorectal adenocarcinoma classification by similar evaluative pattern. Therefore, the aim of present study is classified the colorectal adenocarcinoma by morphofunctional characteristics relating to DNA oxidative stress. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PRIOLLI, DENISE G.; CANELLOI, THAMY P.; LOPES, CAMILA O.; VALDIVIA, JULIO C. M.; MARTINEZ, NATALIA P.; ACARI, DEMETRIUS P.; CARDINALLI, IZILDA A.; RIBEIRO, MARCELO L.. Oxidative DNA damage and beta-catenin expression in colorectal cancer evolution. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, v. 28, n. 5, p. 713-722, . (07/01196-5)

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