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Neuroethological and neurochemical characterization of alkaloids isolated from Erythrina mulungu (Leguminosae-Papilionaceae) flower hydroalcoholic extract

Grant number: 09/11357-1
Support Opportunities:Regular Research Grants
Duration: November 01, 2009 - October 31, 2011
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal Investigator:Renê de Oliveira Beleboni
Grantee:Renê de Oliveira Beleboni
Host Institution: Universidade de Ribeirão Preto (UNAERP). Campus Ribeirão Preto. Ribeirão Preto , SP, Brazil


The epilepsy is a widespread neurological disorder characterized by several social, economical and epidemiological implications. GABA and glutamate pathways dysfunctions play a role in several neurological disorders, including epilepsy. It has been established that a detailed understanding of these pathways and the search for new anticonvulsant drugs may provide new experimental and clinical aproaches for their treatment. Recently, some reports have validated the popular use of Erythrina mulungu (Leguminosae-Papilionaceae) flowers hydroalcoholic extract as an anticonvulsant, analgesic and anxiolitic agent. However, data describing about the molecular mechanism involved in these pharmacological actions are poorly known. The aim of this work is to evaluate the "in vivo" anticonvulsant action of the alkaloids erythravine, 11-alpha-hydroxy-erythravine and erythrosine from E. mulungu as well as to investigate the mode of action of these compounds in GABA and Glutamate synapse function by the use of neuroethological, neurochemical and molecular biology tools, therefore, contributing for a biotechnological approach in this issue. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSA, DAIANE SANTOS; FAGGION, SILMARA APARECIDA; GAVIN, AMANDA SALOMAO; DE SOUZA, MAICON ANDERSON; FACHIM, HELENE APARECIDA; DOS SANTOS, WAGNER FERREIRA; PEREIRA, ANA MARIA SOARES; CUNHA, ALEXANDRA OLIMPIO SIQUEIRA; BELEBONI, RENE OLIVEIRA. Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: Evaluating its anticonvulsant and anxiolytic potential. Epilepsy & Behavior, v. 23, n. 3, p. 205-212, . (09/11357-1)
FAGGION, SILMARA APARECIDA; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; FACHIM, HELENE APARECIDA; GAVIN, AMANDA SALOMAO; DOS SANTOS, WAGNER FERREIRA; SOARES PEREIRA, ANA MARIA; BELEBONI, RENE OLIVEIRA. Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-alpha-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae). Epilepsy & Behavior, v. 20, n. 3, p. 441-446, . (09/11357-1)

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