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Study of cellular mechanisms involved in photodynamic therapy


The concept of Photodynamic Therapy (PDT) is cytotoxicity photoinduction of cells proliferating involving a photosensitizer agent (PS), light source and molecular oxygen. PDT is technique that induces damage to the tumor tissue and is the administration of a photosensitive drug that is selectively retained in neoplastic tissue and produces singlet oxygen when irradiated with a wavelength appropriate in the presence of molecular oxygen. This study used the PS will be the photogem®, a hematoporphyrin derivative produced in Russia and being used in PDT in Brazil and the PDZ®, PS-based chlorine produced in Russia. The PFs will be administered in animals intraperitoneally at doses of 12 mg / kg (HPD) and 8 mg / kg (PDZ). The light source chosen is (Brazil) and used for HPD laser diode at 630 and for chlorin 660 nm QuantumTech intensity of 200 mW/cm and 300 J/cm light dose and the intensity of a PDZ 100 mW/cm and 100 J/cm. This study aims at establishing a basis for diagnosis and therapy, studying the cellular mechanisms of PDT for the combination of the techniques of FT-Raman, electron microscopy, immunohistochemistry, and molecular markers, comparing cellular mechanisms of PDT-induced different photosensitizers and correlating with cellular resistance. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, J. C.; FERREIRA-STRIXINO, J.; FONTANA, L. C.; PAULA, L. M.; RANIERO, L.; MARTIN, A. A.; CANEVARI, R. A. Apoptosis-associated genes related to photodynamic therapy in breast carcinomas. Lasers in Medical Science, v. 29, n. 4, p. 1429-1436, JUL 2014. Web of Science Citations: 9.

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