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Genetic and environmental risk factors to the development of melanoma in Latin America

Grant number: 07/04313-2
Support Opportunities:Regular Research Grants
Duration: April 01, 2008 - March 31, 2010
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Gilles Landman
Grantee:Gilles Landman
Host Institution: Hospital A C Camargo. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil

Abstract

Cutaneous Malignant Melanoma (CMM), a melanocytic neoplasm, has low incidence and high mortality. In 2006 INCA estimated 5.760 new cases in Brazil, observing the highest incidence in the South region. Early diagnosis is the key for a good prognosis. In fact, 05 years survival rates drops from 69% to 14% in the advanced disease. Approximately 10% of all patients with CMM have a first or second degree relative with the same disease, characterizing the Familial Melanoma Syndrome on a clinical basis. There are very few reports on familial melanoma in Latin America. (AU)

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VEICULO: TITULO (DATA)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO DE AVILA, ALEXANDRE LEON; VICTORINO KREPISCHI, ANA CRISTINA; MOREDO, LUCIANA FACURE; MARQUES AGUIAR, TALITA FERREIRA; DA SILVA, FELIPE CARNEIRO; SOARES DE SA, BIANCA COSTA; DE NOBREGA, AMANDA FRANCA; WADDINGTON ACHATZ, MARIA ISABEL; DUPRAT, JOAO PEDREIRA; LANDMAN, GILLES; et al. Germline CDKN2A mutations in Brazilian patients of hereditary cutaneous melanoma. FAMILIAL CANCER, v. 13, n. 4, p. 645-649, . (08/57887-9, 07/04313-2)
PUIG, SUSANA; POTRONY, MIRIAM; CUELLAR, FRANCISCO; PUIG-BUTILLE, JOAN ANTON; CARRERA, CRISTINA; AGUILERA, PAULA; NAGORE, EDUARDO; GARCIA-CASADO, ZAIDA; REQUENA, CELIA; KUMAR, RAJIV; et al. Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma. Genetics in Medicine, v. 18, n. 7, p. 727-736, . (07/04313-2)
SOUZA DE ARAUJO, ERICA SARA; MARCHI, FABIO ALBUQUERQUE; RODRIGUES, TATIANE CRISTINA; VIEIRA, HENRIQUE CURSINO; KUASNE, HELLEN; WADDINGTON ACHATZ, MARIA ISABEL; MOREDO, LUCIANA FACURE; SOARES DE SA, BIANCA COSTA; DUPRAT, JOAO PEREIRA; BRENTANI, HELENA PAULA; et al. Genome-wide DNA methylation profile of leukocytes from melanoma patients with and without CDKN2A mutations. Experimental and Molecular Pathology, v. 97, n. 3, p. 425-432, . (13/07480-8, 12/13963-9, 08/57887-9, 07/04313-2)
TAYLOR, NICHOLAS J.; MITRA, NANDITA; GOLDSTEIN, ALISA M.; TUCKER, MARGARET A.; AVIL, MARIE-FRANCOISE; AZIZI, ESTHER; BERGMAN, WILMA; BISHOP, D. TIMOTHY; BRESSAC-DE PAILLERETS, BRIGITTE; BRUNO, WILLIAM; et al. Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families. JOURNAL OF INVESTIGATIVE DERMATOLOGY, v. 137, n. 12, p. 2606-2612, . (07/04313-2)
TAYLOR, NICHOLAS J.; MITRA, NANDITA; QIAN, LU; AVRIL, MARIE-FRANCOISE; BISHOP, D. TIMOTHY; BRESSAC-DE PAILLERETS, BRIGITTE; BRUNO, WILLIAM; CALISTA, DONATO; CUELLAR, FRANCISCO; CUST, ANNE E.; et al. Estimating CDKN2A mutation carrier probability among global familial melanoma cases using GenoMELPREDICT. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, v. 81, n. 2, p. 386-394, . (07/04313-2)
LACSON, JOHN CHARLES A.; ZAMANI, SHAWN A.; FROES JR, LUIS ALBERTO RIBEIRO; MITRA, NANDITA; QIAN, LU; DOYLE, SCARLET H.; AZIZI, ESTHER; BALESTRINI, CLAUDIA; BISHOP, D. TIMOTHY; BRUNO, WILLIAM; et al. Birth cohort-specific trends of sun-related behaviors among individuals from an international consortium of melanoma-prone families. BMC PUBLIC HEALTH, v. 21, n. 1, . (07/04313-2)

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