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Venoms from neonate and mature Bothrops jararaca snakes: comparison between enzymatic and biological activities, immunoneutralization, chemical composition and ability to induce hemostatic disorders

Grant number: 08/02996-8
Support Opportunities:Regular Research Grants
Duration: November 01, 2008 - October 31, 2010
Field of knowledge:Biological Sciences - Pharmacology - Toxicology
Principal Investigator:Marcelo Larami Santoro
Grantee:Marcelo Larami Santoro
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SENISE, LUANA V.; YAMASHITA, KARINE M.; SANTORO, MARCELO L.. Bothrops jararaca envenomation: Pathogenesis of hemostatic disturbances and intravascular hemolysis. Experimental Biology and Medicine, v. 240, n. 11, p. 1528-1536, . (08/02996-8, 10/08162-1)
SANTORO, MARCELO LARAMI; DO CARMO, THAIS; LOPES CUNHA, BRUNA HELOISA; ALVES, ANDRE FONSECA; ZELANIS, ANDRE; DE TOLEDO SERRANO, SOLANGE MARIA; GREGO, KATHLEEN FERNANDES; SANT'ANNA, SAVIO STEFANINI; BARBARO, KATIA CRISTINA; FERNANDES, WILSON. Ontogenetic Variation in Biological Activities of Venoms from Hybrids between Bothrops erythromelas and Bothrops neuwiedi Snakes. PLoS One, v. 10, n. 12, . (13/07467-1, 10/08162-1, 13/13548-4, 08/02996-8, 09/15413-3, 13/25177-0)
ANTUNES, THATIANE C.; YAMASHITA, KARINE M.; BARBARO, KATIA C.; SAIKI, MITIKO; SANTORO, MARCELO L.. Comparative analysis of newborn and adult Bothrops jararaca snake venoms. Toxicon, v. 56, n. 8, p. 1443-1458, . (08/00266-2, 08/02996-8)
PEICHOTO, MARIA E.; MACKESSY, STEPHEN P.; TEIBLER, PAMELA; TAVARES, FLAVIO L.; BURCKHARDT, PAULA L.; BRENO, MARIA C.; ACOSTA, OFELIA; SANTORO, MARCELO L.. Purification and characterization of a cysteine-rich secretory protein from Philodryas patagoniensis snake venom. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 150, n. 1, p. 79-84, . (08/02996-8)
ELISA PEICHOTO, MARIA; ZYCHAR, BIANCA CESTARI; LUIZ TAVARES, FLAVIO; GONCALVES, LUIS ROBERTO CAMARGO; ACOSTA, OFELIA; SANTORO, MARCELO LARAMI. Inflammatory effects of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom. Experimental Biology and Medicine, v. 236, n. 10, p. 1166-1172, . (08/02996-8, 10/52559-3, 10/08162-1)
SEIBERT, CARLA SIMONE; SANTORO, MARCELO L.; TAMBOURGI, DENISE VILARINHO; SAMPAIO, SANDRA COCCUZZO; TAKAHASHI, HILTON KENJI; PERES, CARMEM MALDONADO; CURI, RUI; SANO-MARTINS, IDA S.. Lonomia obliqua (Lepidoptera, Saturniidae) caterpillar bristle extract induces direct lysis by cleaving erythrocyte membrane glycoproteins. Toxicon, v. 55, n. 7, p. 1323-1330, . (08/02996-8)
PEICHOTO, MARIA E.; PAES LEME, ADRIANA F.; PAULETTI, BIANCA A.; BATISTA, ISABEL CORREIA; MACKESSY, STEPHEN P.; ACOSTA, OFELIA; SANTORO, MARCELO L.. Autolysis at the disintegrin domain of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1804, n. 9, p. 1937-1942, . (08/02996-8)
YAMASHITA, K. M.; NOGUEIRA, T. O.; SENISE, L. V.; CIRILLO, M. C.; GONCALVES, L. R. C.; SANO-MARTINS, I. S.; GIORGI, R.; SANTORO, M. L.. Involvement of circulating platelets on the hyperalgesic response evoked by carrageenan and Bothrops jararaca snake venom. Journal of Thrombosis and Haemostasis, v. 9, n. 10, p. 2057-2066, . (08/02996-8)

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