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Obtainment of antifungal agents from extracts produced by mangrove fungi: isolation and identification of the active compounds

Grant number: 08/06524-3
Support Opportunities:Regular Research Grants
Duration: February 01, 2009 - March 31, 2011
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ana Olívia de Souza
Grantee:Ana Olívia de Souza
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Fungal infections are frequent and responsible for high morbidity and mortality especially in immune-sensitive patients. Treatment with the currently available antifungal substances is long and causes various collateral effects, which justifies the search for new antifungal agents. The Brazilian biodiversity represents a straight and viable source of new molecules to be applied by the chemistry and pharmaceutical industries. Taking in account these aspects, isolated fungi from mangroves were grown in laboratory and their organic extracts were assayed with respect to their antifungal activity. Fifteen microorganisms were selected as potential producers of antifungal agents. The organic extracts will be purified through chromatographic techniques and physical-chemical analysis will be applied to characterize the molecules. Antifungal assays will be performed to guide purification process. This project intends to purify the more effective extracts, in an effort to identify and isolate the antifungal molecule. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OGUIURA, NANCY; CORREA, POLIANA GARCIA; ROSMINO, ISABELLA LEMOS; DE SOUZA, ANA OLIVIA; PASQUALOTO, KERLY FERNANDA MESQUITA. ntimicrobial Activity of Snake beta-Defensins and Derived Peptide. OXIN, v. 14, n. 1, . (08/06524-3, 15/00003-5)

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