Advanced search
Start date

The contribution of necroptosis and apoptosis during acute kidney injury

Grant number: 08/09773-4
Support Opportunities:Regular Research Grants
Duration: March 01, 2009 - February 28, 2011
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Júlio César Martins Monte
Grantee:Júlio César Martins Monte
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Acute kidney injury involves two key mechanisms, namely necrosis and apoptosis, the former representing a non-specific, unregulated form of cell death, whilst the latter is a highly regulated process designed to systematically dismantle damaged cells and maintain homeostasis. The participation of an ever-growing number of molecules in the apoptotic machinery offers a plethora of opportunities for apoptosis modulation. Caspase inhibition have provided valuable efficacy in inhibiting apoptotic cell death in different models of injury, including cerebral, cardiac e kidney.However, the success of anti-apoptotic therapies has been limited, perhaps because of our lack of understanding of complexity of cell death regulation in mammalian cells. Emerging evidence suggests that apoptosis is not the only mechanism of cellular suicide, but rather that cells might choose necroptosis as a mechanism to die. Necroptosis represents a type of non apoptotic cell death mechanism. If several mechanisms are operational, then a combination therapy might provide maximal benefit. In this study, we aim to study the effect of necrostatin-1, which blocks a critical step in necroptosis, in the setting of model of toxic kidney injury by cisplatin and evaluate cytoprotective treatment by combination therapy (anti-apoptotic and anti-necroptotic) (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TRISTAO, VIVIAN REGINA; GONCALVES, PAULA FERNANDA; DALBONI, MARIA APARECIDA; BATISTA, MARCELO COSTA; DURAO, JR., MARCELINO DE SOUZA; MARTINS MONTE, JULIO CESAR. Nec-1 Protects against Nonapoptotic Cell Death in Cisplatin-Induced Kidney Injury. RENAL FAILURE, v. 34, n. 3, p. 373-377, . (08/09773-4)
TRISTAO, VIVIAN REGINA; PESSOA, EDSON A.; NAKAMICHI, RENATA; REIS, LUCIANA A.; BATISTA, MARCELO COSTA; DURAO JUNIOR, MARCELINO DE SOUZA; MARTINS MONTE, JULIO CESAR. Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity. Apoptosis, v. 21, n. 1, p. 51-59, . (08/09773-4)

Please report errors in scientific publications list by writing to: