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Clinical trial with ivermectine for the treatment of Mansonella ozzardi infections

Grant number: 08/10817-6
Support Opportunities:Regular Research Grants
Duration: June 01, 2009 - May 31, 2011
Field of knowledge:Biological Sciences - Parasitology - Helminthology of Parasites
Principal Investigator:Luís Marcelo Aranha Camargo
Grantee:Luís Marcelo Aranha Camargo
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Mansonella ozzardi (Manson, 1897) is a nematode of the Onchocercidae family and it represents one of the eight species of filaria that infects mostly human beings. Since its discovery on the first half of the 20th Century, very little has been said about its pathogenicity. In the middle of the 40's, Brazilian authors, after conducting many surveys to check on the incidence of human Filariosis in Manaus, described the parasite for the first time and, in the 50's and 60's, studied its prevalence in many Amazonian states and in many countries of South and Central America, questioning its pathogenicity and treatment. This study originated after diagnosing 40 patients infected with Mansonella ozzardi during the execution of the FAPESP Project 2007/00531-5 in the municipality of Lábrea, Amazonas state. Presently, Invermectin has been empirically used in the treatment of Mansonelosis, based on the analogous experience of its use in the treatment of Onchocerciasis. There is no controlled study to measure the effectiveness and/or occurrence of collateral effects related to the use of Invermectin to treat M. ozzardi infections. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BASANO, SERGIO DE ALMEIDA; FONTES, GILBERTO; MEDEIROS, JANSEN FERNANDES; DE ALMEIDA ARANHA CAMARGO, JULIANA SOUZA; SOUZA VERA, LUANA JANAINA; PARENTE ARAUJO, MARCOS PAULO; PIRES PARENTE, MAIRA SANTIAGO; MATTOS FERREIRA, RICARDO DE GODOI; BARRETO CRISPIM, PEDRO DI TARIQUE; ARANHA CAMARGO, LUIS MARCELO. Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon. American Journal of Tropical Medicine and Hygiene, v. 90, n. 6, p. 1170-1175, . (08/10817-6)
SOUZA VERA, LUANA JANAINA; BASANO, SERGIO DE ALMEIDA; ALMEIDA ARANHA CAMARGO, JULIANA DE SOUZA; DE FRANCA, ANDONAI KRAUZE; MATTOS FERREIRA, RICARDO DE GODOI; CASSEB, ALMEIDA ANDRADE; MEDEIROS, JANSEN FERNANDES; FONTES, GILBERTO; ARANHA CAMARGO, LUIS MARCELO. Adequação da técnica da PCR para diagnóstico de infecção de Mansonella ozzardi. Revista da Sociedade Brasileira de Medicina Tropical, v. 44, n. 3, p. 380-382, . (08/10817-6)

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