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Determinants and consequences of asymptomatic carriage of malaria parasites: population-based studies in rural Brazilian Amazonia

Grant number: 09/52729-9
Support Opportunities:Regular Research Grants
Duration: October 01, 2009 - September 30, 2011
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Principal Investigator:Marcelo Urbano Ferreira
Grantee:Marcelo Urbano Ferreira
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Despite five decades of intensive control efforts, malaria remains a major public health concern in Brazil. The most recent incidence data available are for 2007, when 458,041 slide-confirmed malaria cases were reported countrywide, 99.9% of which acquired in the Amazon Basin. The increasing interest oh malaria epidemiology in Brazil originates mainly from the high morbidity observed in exposed populations, but subclinical malaria infections are also a major target of research. Here we focus on the epidemiology of asymptomatic malarial infections in two different settings in Brazil: (a) traditional riverine communities and agricultural settlements. We aim to: (a) estimate the prevalence of asymptomatic malaria parasite carriage and characterize risk factors for clinical disease among parasite carriers; (b) estimate the prevalence and risk factors for gametocyte carriage in symptomatic and asymptomatic infections; (c) estimate the risk of subsequent clinical malaria among asymptomatic parasite carriers and non-infected subjects; (d) determine whether subsequent clinical malaria episodes diagnosed during the follow-up of asymptomatic parasite carriers are associated with persistent parasite lineages or with infections with unrelated parasites; (e) compare levels of genetic diversity in parasites recovered from symptomatic and asymptomatic infections. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HUPALO, DANIEL N.; LUO, ZUNPING; MELNIKOV, ALEXANDRE; SUTTON, PATRICK L.; ROGOV, PETER; ESCALANTE, ANANIAS; VALLEJO, ANDRES F.; HERRERA, SOCRATES; AREVALO-HERRERA, MYRIAM; FAN, QI; et al. Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nature Genetics, v. 48, n. 8, p. 953+, . (09/52729-9)
FERREIRA, MARCELO U.; CASTRO, MARCIA C.. Challenges for malaria elimination in Brazil. Malaria Journal, v. 15, . (09/52729-9, 13/17259-7)
LIMA, NATHALIA F.; BASTOS, MELISSA S.; FERREIRA, MARCELO U.. Plasmodium vivax: Reverse transcriptase real-time PCR for gametocyte detection and quantitation in clinical samples. Experimental Parasitology, v. 132, n. 3, p. 348-354, . (09/52729-9)
BARBOSA, SUSANA; GOZZE, AMANDA B.; LIMA, NATHALIA F.; BATISTA, CAMILLA L.; BASTOS, MELISSA DA SILVA; NICOLETE, VANESSA C.; FONTOURA, PABLO S.; GONCALVES, RAQUEL M.; VIANA, SUSANA ARIANE S.; MENEZES, MARIA JOSE; et al. Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia. PLoS Neglected Tropical Diseases, v. 8, n. 8, . (09/52729-9, 13/23770-6, 13/17259-7, 09/12180-8)
CARIAS, LENORE L.; DECHAVANNE, SEBASTIEN; NICOLETE, VANESSA C.; SRENG, SOKUNTHEA; SUON, SEILA; AMARATUNGA, CHANAKI; FAIRHURST, RICK M.; DECHAVANNE, CELIA; BARNES, SAMANTHA; WITKOWSKI, BENOIT; et al. Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein. JOURNAL OF IMMUNOLOGY, v. 202, n. 9, p. 2648-2660, . (09/52729-9)
URUSOVA, DARYA; CARIAS, LENORE; HUANG, YINING; NICOLETE, VANESSA C.; POPOVICI, JEAN; ROESCH, CAMILLE; SALINAS, NICHOLE D.; WITKOWSKI, BENOIT; FERREIRA, MARCELO U.; ADAMS, JOHN H.; et al. Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP. NATURE MICROBIOLOGY, v. 4, n. 9, p. 1486-1496, . (09/52729-9)
SHAW-SALIBA, KATHRYN; CLARKE, DAVID; SANTOS, JORGE M.; MENEZES, MARIA JOSE; LIM, CAEUL; MASCARENHAS, ANJALI; CHERY, LAURA; GOMES, EDWIN; MARCH, SANDRA; BHATIA, SANGEETA N.; et al. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. International Journal for Parasitology, v. 46, n. 11, p. 679-683, . (09/52729-9)
NICOLETE, VANESSA C.; FRISCHMANN, SARAH; BARBOSA, SUSANA; KING, CHRISTOPHER L.; FERREIRA, MARCELO U.. Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein and Clinical Immunity to Malaria in Rural Amazonians. Journal of Infectious Diseases, v. 214, n. 10, p. 1539-1546, . (09/52729-9, 13/23770-6)

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