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Surgical and laboratorial evaluation of homologous equine pericardium in serosal abrasion lesions of small colon in horses


The intra-abdominal adhesions are common complications after abdominal surgeries or surgeries for treatment of equine gastrointestinal diseases, they can result in obstructions, signals of recurrent abdominal pain and volvulos, as well they can occur in human patients, where the adhesions are the most common cause of intestines obstructive processes. Studies have showed that the animals' survival submitted to laparotomy for correction of primary diseases of the small intestine is between 24- 52%. After the advanced of surgical techniques, diagnosis and anesthesia an increase of the survival index could be observed in animals submitted to abdominal surgeries, what show that the adhesions have become more evident and important during the postoperative period. Several studies had been done to check the efficiency of the methods to minimize the adhesions formation, the prevention should be the most important factor because the usual treatment is inefficient and the cost is extremely expensive. Because of this situation the surgeons have paid more attention some basic principles of the surgery and used therapies to minimize them. For example: (1) surgical principle of Halsted and aggressive medical therapy, (2) prevention of the inflammatory initial phase through the blockade of metabolics of the O2, (3) dissolution and precocious removal of the fibrinous exudates using fybrinolitics agents, (4) interference in the apposition of the lesions of the peritoneal surfaces, (5) prokinetic and (6) inhibition of the colagen formation. Ahead of impossibility to use the materials used in human patients, either for economic restrictions and or techniques, the biological membranes have offered a physician-surgical therapeutically possibility in veterinary medicine.The objectives of this project will be to check the intra abdominal adhesions in equine small colon by induced trauma at the serous, and to compare one group treated with biological membrane and one group without membrane. It will be checked 10 horses submitted to flank laparotomy and induced the trauma by abrasion in serous of small colon. After 30 days these animals will be submitted to new procedure for local evaluation and biopsy. (AU)

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