Advanced search
Start date
Betweenand
Related content

New strategies in the search of natural antibiotics: symbiotic microorganisms as sources of compounds and in vivo assay based on Caenorhabditis elegans infection model

Grant number: 08/09540-0
Support Opportunities:Regular Research Grants
Duration: February 01, 2009 - January 31, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Mônica Tallarico Pupo
Grantee:Mônica Tallarico Pupo
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The main goal of this project is the establishment of new strategies for the obtention of natural products with antibiotic activity (antibacterial and anticancer). The strategies are based on two main approaches: 1) The search for new biodiversity niches, which are usually associated to new chemical and biological diversity. In this context, this project aims the chemical study of symbiotic microorganisms. Endophytic microorganisms (fungi and actinobacteria) isolated from medicinal Asteraceae plants and actinobacteria isolated from the mangrove crab (Ucides cordatus) will be cultivated in simple and dual cultures. 2) Establishment of a new in vivo antibacterial assay by using the nematode Caenorhabditis elegans infected by pathogenic bacteria for the screening and identification of antibiotic natural products. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
TITULO 
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARABALLO-RODRIGUEZ, ANDRES M.; MAYOR, CASSIA A.; CHAGAS, FERNANDA O.; PUPO, MONICA T.. Amphotericin B as an inducer of griseofulvin-containing guttate in the endophytic fungus Xylaria cubensis FLe9. Chemoecology, v. 27, n. 5, p. 177-185, . (12/21803-1, 13/07600-3, 08/09540-0, 14/01651-8)
CHAGAS, FERNANDA OLIVEIRA; PESSOTTI, RITA DE CASSIA; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; PUPO, MONICA TALLARICO. Chemical signaling involved in plant-microbe interactions. CHEMICAL SOCIETY REVIEWS, v. 47, n. 5, p. 1652-1704, . (11/12910-6, 08/09540-0, 13/07600-3, 13/50954-0, 12/21803-1)
CHAGAS, FERNANDA O.; RUZZINI, ANTONIO C.; BACHA, V, LARISSA; SAMBORSKYY, MARKYIAN; CONTI, RAPHAEL; PESSOTTI, RITA C.; DE OLIVEIRA, LUCIANA G.; CLARDY, JON; PUPO, MONICA T.. Genome Sequence of Streptomyces sp. Strain RTd22, an Endophyte of the Mexican Sunflower. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 4, n. 4, . (13/07600-3, 08/09540-0, 13/50954-0, 09/17695-6, 08/00812-7, 11/06209-3, 11/12910-6, 11/11703-7)
COUTINHO GALLO, MARGARETH BORGES; CAVALCANTI, BRUNO COELHO; ARAUJO BARROS, FRANCISCO WASHINGTON; DE MORAES, MANOEL ODORICO; COSTA-LOTUFO, LETICIA VERAS; PESSOA, CLAUDIA; BASTOS, JAIRO KENUPP; PUPO, MONICA TALLARICO. Chemical Constituents of Papulaspora immersa, an Endophyte from Smallanthus sonchifolius (Asteraceae), and Their Cytotoxic Activity. CHEMISTRY & BIODIVERSITY, v. 7, n. 12, p. 2941-2950, . (08/09540-0, 04/07935-6, 05/56259-6)
ALMEIDA, MARILIA O.; LOPES, ADRIANA A.; ROBERTO, PATRICIA G.; BERTONI, BIANCA W.; PUPO, MONICA T.. Unveiling the fungal biotransformation of hydralazine using C-13-precursor. PHYTOCHEMISTRY LETTERS, v. 26, p. 55-59, . (08/09540-0, 13/07600-3)
CONTI, RAPHAEL; CHAGAS, FERNANDA OLIVEIRA; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; DA PAIXAO MELO, WEILAN GOMES; DO NASCIMENTO, ANDREA MENDES; CAVALCANTI, BRUNO COELHO; DE MORAES, MANOEL ODORICO; PESSOA, CLAUDIA; COSTA-LOTUFO, LETICIA VERAS; KROGH, RENATA; et al. Endophytic Actinobacteria from the Brazilian Medicinal Plant Lychnophora ericoides Mart. and the Biological Potential of Their Secondary Metabolites. CHEMISTRY & BIODIVERSITY, v. 13, n. 6, p. 727-736, . (08/00812-7, 08/09540-0, 13/07600-3, 09/17695-6, 12/21803-1, 15/01001-6)
LOPES, ADRIANA A.; PINA, EDIEIDIA S.; SILVA, DENISE B.; PEREIRA, ANA MARIA S.; DA SILVA, MARIA FATIMA DAS GRACAS F.; DA COSTA, FERNANDO B.; LOPES, NORBERTO P.; PUPO, MONICA T.. A biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI imaging. CHEMICAL COMMUNICATIONS, v. 49, n. 85, p. 9989-9991, . (08/09540-0, 08/01220-6)
CHAGAS, FERNANDA O.; DIAS, LUIS G.; PUPO, MONICA T.. New perylenequinone derivatives from the endophytic fungus Alternaria tenuissima SS77. Tetrahedron Letters, v. 57, n. 29, p. 3185-3189, . (08/09540-0, 09/17695-6, 13/07600-3, 13/08166-5)
TUICHE, MAYRA VENDRAMINI; LOPES, ADRIANA APARECIDA; SILVA, DENISE BRENTAN; LOPES, NORBERTO PEPORINE; PUPO, MONICA TALLARICO. Direct MALDI-TOF/TOF analyses of unnatural beauvericins produced by the endophytic fungus Fusarium oxysporum SS46. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 24, n. 4, p. 433-438, . (08/09540-0, 13/07600-3)
CHAGAS, FERNANDA O.; PUPO, MONICA T.. Chemical interaction of endophytic fungi and actinobacteria from Lychnophora ericoides in co-cultures. MICROBIOLOGICAL RESEARCH, v. 212, p. 10-16, . (09/17695-6, 08/09540-0, 13/07600-3)
CARABALLO-RODRIGUEZ, ANDRES M.; DORRESTEIN, PIETER C.; PUPO, MONICA T.. Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides. SCIENTIFIC REPORTS, v. 7, . (12/21803-1, 13/07600-3, 08/09540-0, 14/01651-8)
CHAGAS, FERNANDA O.; DIAS, LUIS G.; PUPO, MONICA T.. A Mixed Culture of Endophytic Fungi Increases Production of Antifungal Polyketides. Journal of Chemical Ecology, v. 39, n. 10, p. 1335-1342, . (07/06057-3, 08/09540-0, 09/17695-6, 13/07600-3)
CHAGAS, FERNANDA OLIVEIRA; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; DORRESTEIN, PIETER C.; PUPO, MONICA TALLARICO. Expanding the Chemical Repertoire of the Endophyte Streptomyces albospinus RLe7 Reveals Amphotericin B as an Inducer of a Fungal Phenotype. Journal of Natural Products, v. 80, n. 5, p. 1302-1309, . (08/09540-0, 13/07600-3, 14/01651-8, 09/17695-6, 12/21803-1)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.