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Study on the influence of co-solvents on thermodynamic properties of proteins in solution

Grant number: 08/11232-1
Support Opportunities:Regular Research Grants
Duration: April 01, 2009 - March 31, 2011
Field of knowledge:Engineering - Chemical Engineering
Principal Investigator:Pedro de Alcântara Pessôa Filho
Grantee:Pedro de Alcântara Pessôa Filho
Host Institution: Escola Politécnica (EP). Universidade de São Paulo (USP). São Paulo , SP, Brazil


An investigation on the influence of both ionic and non-ionic co-solvents upon the thermodynamic properties of proteins in solution is proposed in this research plan. The experimental assays comprise the determination of osmotic pressure data (through membrane osmometry), light scattering data and water activity data (through the isopiestic methodology). The co-solvents which are to be investigated are salts (ammonium sulfate, sodium sulfate and sodium chloride) and polymers (polyethylene glycol samples of different chain sizes and the block copolymer F38). The set of proteins to be studied comprise bovine serum albumin, lysozyme, alpha-lactalbumin, beta-lactoglobulin, insulin and urate-oxidase. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRANCO, L. F. M.; PESSOA FILHO, P. DE A.. On the relationship between the solubility of proteins and the osmotic second virial coefficient. Brazilian Journal of Chemical Engineering, v. 30, n. 1, p. 95-104, . (08/11232-1, 09/06575-0)
MERCIER FRANCO, LUIS FERNANDO; MATTEDI, SILVANA; PESSOA FILHO, PEDRO DE ALCANTARA. A new approach for the thermodynamic modeling of the solubility of amino acids and beta-lactam compounds as a function of pH. Fluid Phase Equilibria, v. 354, p. 38-46, . (11/22070-5, 08/11232-1)
MERCIER FRANCO, LUIS FERNANDO; PESSOA FILHO, PEDRO DE ALCANTARA. On the solubility of proteins as a function of pH: Mathematical development and application. Fluid Phase Equilibria, v. 306, n. 2, p. 242-250, . (09/06575-0, 08/11232-1)

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