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Chronic cardac adaptation to acute aorta regurgitation in rats

Grant number: 09/51222-8
Support Opportunities:Regular Research Grants
Duration: August 01, 2009 - July 31, 2011
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Beatriz Bojikian Matsubara
Grantee:Beatriz Bojikian Matsubara
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Myocardial remodeling following volume overload is not well known. This is a relevant matter in countries where cardiac valve insufficiency is still prevalent. We hypothesized that in vivo left ventricular dysfunction caused by aorta regurgitation (AR) in rats is not associated with pulmonary congestion. Also, it is possible that ventricular dysfunction is associated with changes in intracellular calcium homeostasis without myocardial fibrosis. The aims of the present study are: 1-to evaluate the temporal evolution of ventricular adaptation to acute aorta regurgitation, identifying the markers of decompensated hypertrophy, 3-to identify the myocardial collagenolytic activity early after volume overload; 4-to analyze the pattern of heavy chain myosin and the RNA expression for phospholamban, ryanodine receptors and SERCA2. Methods: after surgical AR or SHAM surgery, Wistar rats will be followed for 16 weeks. Serial Doppler-echocardiograms will be performed. After this period, animals will be killed and myocardial samples will be saved for biochemical and histological analysis. One week after the surgery, six animals from each group will be killed for analysis of myocardial collagenolytic activity. The Intitutional's Ethics Committee for Research on Animals approved all procedures (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRATUCCI DE GOBBI, JULIANA IRANI; MIEKO OMOTO, ANA CAROLINA; SIQUEIRA, TAMIRES FERREIRA; MATSUBARA, LUIZ SHIGUETO; ROSCANI, MELIZA GOI; MATSUBARA, BEATRIZ BOJIKIAN. Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats. Physiology & Behavior, v. 144, p. 124-128, . (09/51222-8, 11/17575-0)

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